Summary
A case of the lung cancer associated with marked elevation of serum (7820 IU/l) and of urinary amylase (2225 IU/l) was autopsied. Material was examined histopathologically, electronmicroscopically and biochemically. The pulmonary tumor tissues showed histological pattern of papillary adenocarcinoma. In addition to the small round bodies which were very similar to secretory glanules, many large round bodies were noticed, diffusely distributed in the tumor cell. These large round bodies ranged from 0.2 to 0.7 μm in diameter and showed a lamellar or annular pattern. The soluble phase of the homogenized pulmonary tumor tissues had an amylase level of 11,300 IU/g of protein, which consisted of S-type isoamylase with minor components. Cholesterol, triglyceride and phospholipid were also present at greater concentration in the tumor tissue than the normal pulmonary tissue. The large round bodies appeared too, to be amylase including bodies from the electronmicroscopical and biochemical findings.
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Abe, S., Mikami, T., Kaji, H., Terai, T., Sakai, E., Osaki, G.: A case of carcinomatous pleurisy with specific isoenzyme pattern of amylase. Ninon Kyobu Rinshyo 32, 906–910 (1973)
Amman, R.M., Berk, J.E., FridhandlerM, L., Ueda, M., Wegmann, W.: Hyperamylasemia with carcinoma of lung. Ann. Intern. Med. 78, 521–525 (1973)
Ende, N.: Amylase activity in body fluid. Cancer 14, 1109–1114 (1961)
Flood, T.G., Schuerche, C., Dorazio, R.C., Bowers, G.N.: Marked hyperamylasemia associated with carcinoma of lung. Clin. Chem. 24, 1207–1212 (1978)
Gasser, P.: Über erhöhte Serumamylase bei bösartigen Tumoren. Helv. Med. Act. 26, 687–690 (1959)
Gomi, K., Kameya, T., Tsumuraya, M., Shimosato, Y., Zeze, F., Abe, K., Yoneyama, T.: Ultrastructural, histochemical and biochemical studies of two cases with amylase, ACTH and β-MSH producing tumor. Cancer 38, 1645–1654 (1976)
Handler, S.: Amylase production by bronchogenic small cell carcinoma. Minn. Med. 58, 299–231 (1975)
Harada, K., Kitamura, M.: Amylase isoenzyme observed in a case of primary lung cancer. Igaku to Seibutsu 82, 155–158 (1971)
Honma, H., Tamura, M., Mochizuki, H., Kitamura, M., Yoshida, M., Nakayama, T., Harada, K.: Malignant tumors showing specific isoenzyme pattern. Nippon Rinsho 29, 2276–2283 (1971)
Ioachin, H.L.: Present trends in lung cancer. The lung structure, function and disease, p. 192. Baltimore: The Williams and Wilkins Comp. 1978
Kameya, T., Zeze, F., Takeuchi, T., Kishi, K., Yamaguchi, N., Kasamatsu, T., Sonoda, T.: An autopsy case of amylase producing lung cancer. Internal Medicine 44, 174–177 (1979)
Miyawaki, M., Matsuo, T., Nakagawa, M., Tokumitsu, S.: Amylase producing gastric cancer. Nippon Rinsho 35, 3444–3445 (1977)
Okada, S., Kubota, M., Tarubayshi, K., Kumano, M., Tenkawa, H., Shimizu, M.: Two cases of alveolar cell carcinoma associating with hyperamylasemia. Lung Cancer 13, 266 (1973)
Oshima, M., Omori, T., Hiasa, Y., Murata, Y., Maruyama, H., Yamaguchi, S., Tsujimoto, H., Takashima, M.: A case of lung cancer associating with elevation of amylase activity in serum, urine and pleural fluid. Gan no Rinsho 24, 1066–1070 (1978)
Otsuki, M., Yuu, H., Maeda, M., Saeki, S., Yamasaki, T., Baba, S.: Amylase in the lung. Cancer 39, 1656–1663 (1977)
Sirsat, A.V., Talardekar, R.V., Shrikhando, S.S., Vyas, J.J.: Serum isoamylase in lung cancer correlation with histological feature of the tumor. Ind. J. Cancer 13, 267–271 (1976)
Sudo, K., Kanno, T.: Properties of the amylase produced in the carcinoma of the lung. Clin. Chim. Acta 73, 1–12 (1976)
Weiss, M.J., Edmondson, H.A., Wertman, M.: Elevated serum amylase associated with bronchigenic carcinoma. Am. J. Clin. 21, 1057–1061 (1951)
Yamamoto, T.: Respiratory system. In: Fine structure of cell and tissues, II, p. 239. Tokyo: Igaku Shoin 1972
Yokosuka, T., Kozu, T., Ohuchi, H., Tamai, M., Hirayama, A., Shizume, K.: Primary ovarian carcinoma associated with hyperamylasemia. Igaku no Ayumi 93, 107–119 (1975)
Yokoyama, M., Natsuizaka, T., Ishii, Y., Ohshima, S., Kasagi, A., Tateno, S.: Amylase-producing lung cancer. Cancer 40, 766–772 (1977)
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Morohoshi, T., Nakamura, N., Hayashi, K. et al. Amylase producing lung cancer. Virchows Arch. A Path. Anat. and Histol. 387, 125–132 (1980). https://doi.org/10.1007/BF00430694
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DOI: https://doi.org/10.1007/BF00430694