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Microbial growth dynamics on the basis of individual budgets

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Abstract

The popular theories for microbial dynamics by Monod, Pirt and Droop are shown to be special cases of a model for individual budgets, in which growth and maintenance are on the expense of reserve materials. The dynamics of reserve materials is a first order process with a relaxation time proportional to cell length; maintenance is proportional to cell volume, and uptake, which depends hyperbolically on substrate density, is proportional to cell volume as well. Because of the latter, population dynamics depends on the behaviour of the individuals in a simple way, such that the cell volume distribution has no quantitative effect.

When uptake is proportional to the surface area of the cell, which is realistic from a physical point of view, the relation between the individual level and the population one becomes more complicated and the cell size and shape distribution affects population dynamics. It is shown how the changing shape of rods modifies uptake and, consequently, growth.

The concept of energy conductance, defined as the ratio, of the maximum surface area specific uptake and the volume specific energy reserve has been introduced in the analysis of microbial dynamics. The first tentative results indicate that the value for E. coli is close to the mean value for a wide variety of animals.

Properties of the model for cell suspension at constant substrate densities are analyzed and tested against a variety of experimental data from the literature on both the individual and the population level.

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Authors and Affiliations

  1. Biological Laboratory, Free University, De Boelelaan 1087, 1081 HV, Amsterdam, The Netherlands

    S. A. L. M. Kooijman, E. B. Muller & A. H. Stouthamer

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  1. S. A. L. M. Kooijman
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  2. E. B. Muller
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  3. A. H. Stouthamer
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Kooijman, S.A.L.M., Muller, E.B. & Stouthamer, A.H. Microbial growth dynamics on the basis of individual budgets. Antonie van Leeuwenhoek 60, 159–174 (1991). https://doi.org/10.1007/BF00430363

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