Summary
Of 743 first degree relatives of diabetics in whom oral glucose tolerance tests had been performed in 1967 488 were re-tested in 1972. Among the original “normals” (n = 353) 17.6% had developed a “subclinical” and 1.3% an “overt diabetes” within 5 years. The original “subclinical diabetics” (n = 118) showed a remission to “normal” in 35.6% and a progression to “overt diabetes” in 13.6%. 3 out of the 17 formerly “overt diabetics” were found to be “normal” after 5 years and 3 were “subclinical diabetics”. Thus the performance of an oral glucose tolerance test is of limited prognostic value in the individual case. In both studies a higher prevalence of abnormal test results occurred in the older age groups and in overweight subjects. Remission or deterioration did not depend, however, on age or on weight changes. The frequency of abnormal tests was higher in males than in females, but the tendency towards the development of diabetes was more pronounced in females, in accordance with a previous observation of a higher age dependance of glucose tolerance in females.
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Aspevik, E., Jorde, R., Raeder, S.: The diabetes survey in Bergen, Norway, 1956. Acta med. scand. 196, 161–169 (1974)
Berger, M., Baumhoff, E., Gries, F.A.: Gewichtsreduktion und Glukose-Intoleranz bei Adipositas, eine Verlaufsstudie über 5 Jahre. 10. Congress of the German Diabetes Association, Ulm, 1975 (abstract)
Danowski, T.S., Aarons, J.H., Hydrowitz, J.D., Wingert, J.P.: Utility of equivocal glucose tolerance. Diabetes 19, 524–526 (1970)
Diabetes mellitus, report of a WHO expert committee. Wld. Hlth. Org. techn. Rep. Ser. 310, 1965
Documenta Geigy, wissenschaftliche Tabellen. 7. Aufl. Basel, 1968
Fajans, S.S.: The definition to chemical diabetes. Metabolism 22, 211–217 (1973)
Fajans, S.S., Conn, J.W.: Prediabetes, subclinical diabetes and latent clinical diabetes: interpretation, diagnosis and treatment. In: On the nature and treatment of diabetes. Amsterdam, New York, London, Milan, Tokyo, Buenos Aires: 641–656, 1965
Fajans, S.S., Floyd, J.C., Pek, S., Conn, J.W.: Studies on the natural history of asymptomatic diabetes in young people. Metabolism 22, 327–336 (1973)
Hoffmann, W.S.: A rapid photoelectric method for the determination of glucose in blood and urine. J. biol. Chem. 120, 51 (1937)
Köbberling, J., Appels, A., Köbberling, G., Creutzfeldt, W.: Glukosebelastungstests bei 727 Verwandten ersten Grades von Altersdiabetikern. Dtsch. med. Wschr. 94, 416–421 (1969)
Köbberling, J., Creutzfeldt, W.: Comparison of different methods for the evaluation of the oral glucose tolerance test. Diabetes 19, 870–877 (1970)
Olefsky, J.M., Reaven, G.M.: Insulin and Glucose responses to identical oral glucose tolerance tests performed forty eight hours apart. Diabetes 23, 449–453 (1974)
O'Sullivan, J.B., Hurwitz, D.: Spontaneous remissions in early diabetes mellitus. Arch. intern. Med. 117, 769 (1966)
O'Sullivan, J.B., Mahan, C.M.: Prospective study of 352 young patients with chemical diabetes. New Engl. J. Med. 278, 1038–1041 (1968)
Report by the Birmingham diabetes survey working party: Five year follow-up report on the Birmingham diabetes survey of 1962. Brit. med. J. 1970/III, 301–305
Strauss, W.T., Hales, C.N.: Plasma insulin in minor abnormalities of glucose tolerance: a 5 year follow-up. Diabetologia 10, 237–243 (1974)
Toeller, M., Knußmann, R.: Reproducibility of oral glucose tolerance tests with three different loads. Diabetologia 9, 102–107 (1973)
Walker, J.B., Brown, P.E.: Early diabetes. A five year follow-up of diabetes in an English community. Lancet 1964/II, 246–248
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Köbberling, J., Kattermann, R. & Arnold, A. Follow-up of “non-diabetic” relatives of diabetics by retesting oral glucose tolerance after 5 years. Diabetologia 11, 451–456 (1975). https://doi.org/10.1007/BF00429915
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DOI: https://doi.org/10.1007/BF00429915