Abstract
Food deprivation significantly increases self-administration of cocaine in both rats and rhesus monkeys. The objective in the present investigation was to determine the effects of varying deprivational states on the level of IV low-dose (0.1 mg/kg/infusion) cocaine self-administration in rats. In the first experiment, 32 naive rats were assigned randomly to four equal-sized groups. Two groups self-administered cocaine, the other two saline over two consecutive 10-day phases. Across phase 1 all animals were free-feeding (FF), while in phase 2, one cocaine- and one saline-reinforced group were subjected to restricted feeding until they reached 80% free-feeding weight (FFW). Results showed that cocaine-reinforced responding was related inversely to body weight. In experiment 2 another 32 rats, reduced to 80% FFW, were assigned to four equal-sized groups. Two groups self-administered cocaine, the other two saline over two consecutive 10-day phases. Across phase 1 all animals were maintained at 80% FFW, while in phase 2, one cocaine- and one saline-reinforced group were abruptly food satiated. Findings showed that cocaine-reinforced responding decreased rapidly to low levels. Finally, the group of cocaine-reinforced rats maintained at 80% FFW across both phases of experiment 2 were also abruptly food satiated. Again, responding decreased rapidly to low levels.
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References
Campbell BA, Fibiger HC (1971) Potentiation of amphetamine-induced arousal by starvation. Nature 233:424–425
Carroll ME (1982) Rapid acquisition of oral phencyclidine self-administration in food-deprived and food-satiated rhesus monkeys: Concurrent phencyclidine and water choice. Pharmacol Biochem Behav 17:341–346
Carroll ME (1984) Effects of pentobarbital and d-amphetamine on oral phencyclidine self-administration in rhesus monkeys. Pharmacol Biochem Behav 20:137–143
Carroll ME, Boe IN (1982) Increased intravenous drug self-administration during deprivation of other reinforcers. Pharmacol Biochem Behav 17:563–567
Carroll ME, Boe IN (1984) Effects of dose on increased etonitazene self-administration by rats due to food deprivation. Psychopharmacology 82:151–152
Carroll ME, France CP, Meisch RA (1979) Food deprivation increases oral and intravenous drug intake in rats. Science 205:319–321
Carroll ME, France CP, Meisch RA (1981) Intravenous self-administration of etonitazine, cocaine and phencyclidine in rats during food deprivation and satiation. J Pharmacol Exp Ther 217:241–247
Carroll ME, Henningfield JE, Meisch RA (1978) Factors determining oral intake of ethanol and other drugs by rats and rhesus monkeys. Paper presented at the symposium on substance abuse: Behavioral Aspects, American Psychological Association Meeting, Toronto
Carroll ME, Meisch RA (1979) Effects of food deprivation on etonitazine consumption in rats. Pharmacol Biochem Behav 10:155–159
Carroll ME, Meisch RA (1980a) Oral phencyclidine (PCP) self-administration in rhesus monkeys: Effects of feeding conditions. J Pharmacol Exp Ther 214:339–346
Carroll ME, Meisch RA (1980b) The effects of feeding conditions on drug-reinforced behavior: Maintenance at reduced body weight versus availability of food. Psychopharmacology 68:121–124
Carroll ME, Meisch RA (1981) Determinants of increased drug self-administration due to food deprivation. Psychopharmacology 74:197–200
Carroll ME, Stotz DC, Kliner DJ, Meisch RA (1984) Self-administration of orally-delivered methohexital in rhesus monkeys with phencyclidine or pentobarbital histories: Effects of food deprivation and satiation. Pharmacol Biochem Behav 20:145–151
de la Garza R, Bergman J, Hartel CR (1981) Food deprivation and cocaine self-administration. Pharmacol Biochem Behav 15:141–144
Lang WJ, Latiff AA, McQueen A, Singer G (1977) Self-administration of nicotine with and without a food delivery schedule. Pharmacol Biochem Behav 7:65–70
Mabry PD, Campbell BA (1975) Potentiation of amphetamine induced arousal by food deprivation: Effects of hypothalamic lesions. Physiol Behav 14:85–88
Martin A (1982) Acquisition and maintenance of pentobarbital self-injection behaviour in rats: Effects of bicuculline Ro 15/1788, naloxone and haloperidol. Honours thesis, La Trobe University
Oei TPS (1983) Effects of body weight reduction and food deprivation on cocaine self-administration. Pharmacol Biochem Behav 19:453–455
Oei TPS, Singer G (1979) Effects of a fixed time schedule and body weight on ethanol self-administration. Pharmacol Biochem Behav 10:767–770
Oei TPS, Singer G, Jefferys D (1980) The interaction of a fixed time food delivery schedule and body weight on self-administration of narcotic analgesics. Psychopharmacology 67:171–176
Papasava M, Oei TPS, Singer G (1981) Low dose cocaine self-administration by naive rats: Effects of body weight and a fixed-time one minute food delivery schedule. Pharmacol Biochem Behav 15:485–488
Papasava M, Singer G (1983) The effect of body weight and dose on phentermine self-administration in naive rats. Neurosci Lett Sup 11:67
Pickens R (1968) Self-administration of stimulants by rats. Int J Addict 3:215–221
Pickens R, Thompson T (1968) Cocaine reinforced behavior in rats: Effects of reinforcement magnitude and fixed-ratio size. J Pharmacol Exp Ther 161:122–129
Pickens R, Thompson T, Yokel RA (1970) Characteristics of amphetamine self-administration by rats. In Ellinwood EH, Cohen S (eds) Current concepts of amphetamine abuse. US Govt Printing Office, Washington DC, pp 43–48
Pilotto R, Singer G, Overstreet D (1984) Self-injection of diazepam in naive rats: Effects of dose, schedule and receptor blockade of different receptors. Psychopharmacology 84:174–177
Singer G, Oei TPS, Wallace M (1982) Schedule-induced self-injection of Drugs. Neurosci Biobehav Rev 6:77–83
Takahashi RN, Singer G (1979) Self-administration of Δ 9-Tetrahydrocannabinol by rats. Pharmacol Biochem Behav 11:737–740
Takahashi RN, Singer G, Oei TPS (1978) Schedule induced self-injection of d-amphetamine by naive animals. Pharmacol Biochem Behav 9:857–861
Yokel RA, Pickens R (1973) Self-administration of optical isomers of amphetamine and methylamphetamine by rats. J Pharmacol Exp Ther 187:27–33
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Papasava, M., Singer, G. Self-administration of low-dose cocaine by rats at reduced and recovered body weight. Psychopharmacology 85, 419–425 (1985). https://doi.org/10.1007/BF00429657
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DOI: https://doi.org/10.1007/BF00429657