Abstract
For over 30 days male Wistar rats drank a concentrated aqueous suspension of hashish in the absence of alternative fluids, but they rejected the drug when water was also made available. In another experiment rats given a choice between water and varying concentrations of hashish also rejected concentrated suspensions, but they appeared less reluctant to drink dilute concentrations. Neither a schedule of alternate-day presentation of hashish nor forced electrical stimulation of lateral hypothalamus induced rats to increase their home-cage intake of an aversive concentration of hashish, suggesting that the enhanced consumption of concentrated ethanol solutions obtained with these two procedures is not due to a nonspecific tendency to ingest any drug offered. Thus rats are generally reluctant to self-administer hashish via the oral route, and their reluctance is not affected by several procedures which can increase their intake of other drugs.
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Corcoran, M.E., Amit, Z. Reluctance of rats to drink hashish suspensions: Free-choice and forced consumption, and the effects of hypothalamic stimulation. Psychopharmacologia 35, 129–147 (1974). https://doi.org/10.1007/BF00429580
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DOI: https://doi.org/10.1007/BF00429580