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Drug-induced decrement in spatial reversal learning in the white rat

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Summary

This study investigated the effects of LSD-25, amphetamine sulfate and chlorpromazine on a simple spatial reversal learning problem in a water-filled maze. Following subcutaneous injections of 0.50 and 0.52 mg/ kg of LSD-25, albino rats were significantly handicapped in acquiring a reversed turning response. The performance of groups given 0.13 mg/kg LSD-25, 1 mg/kg chlorpromazine and 2 mg/kg amphetamine sulfate was not reliably different from a Ringer's-injected control group.

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References

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Authors and Affiliations

  1. Veterans Administration Hospital, Coatesville, Pennsylvania

    Chester R. Wilpizeski (Research Associate) & Charles L. Hamilton

  2. Dept. of Otolaryngology, Jefferson Medical College Hospital, 19107, Philadelphia, Pennsylvania, USA

    Chester R. Wilpizeski (Research Associate)

Authors
  1. Chester R. Wilpizeski
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  2. Charles L. Hamilton
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VA trainee in physiological psychology.

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Wilpizeski, C.R., Hamilton, C.L. Drug-induced decrement in spatial reversal learning in the white rat. Psychopharmacologia 6, 475–479 (1964). https://doi.org/10.1007/BF00429574

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  • DOI: https://doi.org/10.1007/BF00429574

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