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Comparison of a placebo, N-dimethyltryptamine, and 6-hydroxy-N-dimethyltryptamine in man

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Summary

  1. 1.

    Five human subjects received intramuscularly at weekly intervals a placebo and equal doses of 6-hydroxy-N-dimethyltryptamine (6-HDMT) and N-dimethyltryptamine (DMT) (1 mg/kg, 4 subjects; 0.75 mg/kg, 1 subject).

  2. 2.

    DMT produced markedly significant mental effects including anxiety, hallucinations, and perceptual distortions and autonomic changes consisting of pupillary dilatation, increase in systolic and diastolic blood pressure, and a decrease in the kneejerk threshold. These effects appeared within 15–30 minutes and subsided within 1–2 hours.

  3. 3.

    The effects of 6-HDMT were not significantly different from those produced by a placebo.

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References

  • Isbell, H., R. E. Belleville, H. F. Fraser, A. Wikler and C. E. Logan: Studies on lysergic acid diethylamide (LSD-25). I. Effects in former morphine addicts and development of tolerance during chronic intoxication. Arch. Neurol. Psychiat. (Chic.) 76, 468–478 (1956).

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  • Szara, S., and E. Hearst: The 6-hydroxylation of tryptamine derivatives: A way of producing psychoactive metabolites. Ann. N.Y Acad. Sci. 96, 134–141 (1962).

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Authors and Affiliations

  1. National Institute of Mental Health, Addiction Research Center, PHS Hospital, Lexington, Kentucky, USA

    D. E. Rosenberg, Harris Isbell & E. J. Miner

Authors
  1. D. E. Rosenberg
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  2. Harris Isbell
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  3. E. J. Miner
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Rosenberg, D.E., Isbell, H. & Miner, E.J. Comparison of a placebo, N-dimethyltryptamine, and 6-hydroxy-N-dimethyltryptamine in man. Psychopharmacologia 4, 39–42 (1963). https://doi.org/10.1007/BF00429362

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  • DOI: https://doi.org/10.1007/BF00429362

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