Abstract
Evidence is presented which suggests that lithium modifies the mood and behavioral alterations resulting from IV methylphenidate. Specifically, lithium significantly reduces the level of arousal-activation, euphoria-grandiosity, and the total score of manic-state ratings following a methylphenidate challenge. In addition, lithium appears to be capable of modifying the growth hormone response to methylphenidate.
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References
Angrist B, Gershon S (1979) Variable attenuation of amphetamine effects by lithium. Am J Psychiatry 136:806–810
Beigel A, Murphy DL (1971) Assessing clinical characteristics of the manic state. Am. J. Psychiatry 128:688–694
Brown WA, Van Woert MH, Ambani JM (1973) Effect of apomorphine on growth hormone and insulin. Hormones 3:193–213
Chiueh CC, Moore KK (1975) d-Amphetamine-induced release of ‘newly synthesized’ and ‘stored’ dopamine from the caudate nucleus in vivo. J Pharmacol Exp Ther 192:642–653
Cronson AJ, Flemenbaum A (1978) Antagonism of cocaine highs by lithium. Am J Psychiatry 135:856–857
Faraj GA, Israili JM, Perel ML, Jenkins ML, Holtzman SG, Cucinell SA, Dayton PG (1974) Metabolism and disposition of methylphenidate-14C: Studies in man and animals. J Pharmacol Exp Ther 191:535–547
Flemenbaum A (1974) Does lithium block the effects of amphetamines? A report of three cases. Am J Psychiatry 131:820–821
Green RA, Bigelow L, O'Brien P, Stahl D, Wyatt RJ (1977) The inpatient behavioral rating scale: A 26-item scale for recording nursing observations of patients' mood and behavior. Psychol Rep 40:543–549
Huey LY, Janowsky DS, Judd LL, Abroms A, Hubbard B (1977) Methylphenidate antagonism by lithium. In: New research abstracts of the American Psychiatric Association, p 8
Janowsky DS, Davis J (1976) Methylphenidate, dextroamphetamine, and levamphetamine: Effects on schizophrenic symptoms. Arch Gen Psychiatry 33:304–308
Janowsky DS, Huey LY, Stroms L, Judd LL (1977) Methylphenidate hydrochloride effects on psychological tests in acute schizophrenic and nonpsychotic patients. Arch Gen Psychiatry 134:189–194
Janowsky DS, El-Yousef M, Davis J, Sekerke HJ (1973) Provocation of schizophrenic symptoms by intravenous administration of methylphenidate. Arch Gen Psychiatry 28:185–191
Judd LL, Hubbard B, Janowsky DS, Huey LY, Attewell P (1977) The effects of lithium carbonate upon affect, mod, and personality of normal subjects. Arch Gen Psychiatry 34:346–354
Kim S, Sherman L, Kolodny HD (1972) Attenuation by haloperidol of human serum growth hormone (HGH) response to insulin. Clin Res 19:718
Lal S, Sourkes TL (1972) Potentiation and inhibition of the amphetamine stereotyping in rats by neuroleptics and other agents. Arch Int Pharmacodyn Ther 199:289–301
Martin JB (1972) Neural regulation of growth hormone secretion. N Engl J Med 288:1384–1393
McNair D, Lorr M, Droppleman (1971) EITS manual for the profile of mood states (research version). Educational and Testing Service, San Diego
Muller EE, Samano S, Arimura A (1967) Blockade of release of growth hormone by brain norepinephrine depletors. Endocrinology 80:471–476
Parker DC, Sassin JF, Mace JW (1969) Human growth hormone release during sleep: Electroencephalographic correlation. J Clin Endocrinol Metab 29:871–874
Parker DC, Rossman LG, Vander Laan E (1973) Sleep-related nyctohumeral and briefly episodic variation in human plasma prolactin concentrations. J Clin Endocrinol Metab 36:119–124
Rees L, Butler PW, Gosling C, Besser G (1970) Adrenergic blockade and the corticosteroid and growth hormone response to methamphetamine. Nature 228:565–566
Reitan RM (1966) A research program on the psychological effects of brain lesions in human beings. In: Ellis NR (ed) International review of research in mental retardation, vol 1. Academic, New York, p 153
Sachar EJ, Altman N, Gruen P, Glassman A, Halpern FS, Sassin J (1975) Growth hormone response to levodopa. Arch Gen Psychiatry 32:502–503
Scheel-Krueger J (1972) Some aspects of the mechanism of action of various stimulant amphetamine analogues. Psychiatr Neurol Neurochir 75:176–192
Sherman L, Sooseng K, Benjamin F, Kolodny HD (1971) Effect of chlorpromazine on serum growth hormone concentration in man. N Engl J Med 284:72–74
Smith RC, Davis JM (1977) Comparative effects of d-amphetamine, l-amphetamine, and methylphenidate on mod in man. Psychopharmacology 53:1–12
Spitzer RL, Endicott J (1975) Schedule for affective disorders and schizophrenia (SADS). New York State Psychiatric Institute, Biometrics Research, New York
Spitzer RL, Endicott J, Robins E (1975) Research diagnostic criteria. New York State Department of Mental Hygiene and New York State Psychiatric Institute Biometrics Research, New York
Tecce JJ, Cole JO (1974) Amphetamine effects in man: Paradoxical drowsiness and lowered electrical brain activity (CNV). Science 185:451–453
Toivola PTK, Gale CC (1972) Stimulation of growth hormone release by microinjection of norepinephrine into hypothalamus of baboons. Endocrinology 90:895–902
Van Kammen DP, Murphy DL (1975) Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment. Psychopharmacologia 44:215–224
Wald D, Ebstein RP, Belmaker RH (1978) Haloperidol and lithium blocking of the mood response to intravenous methylphenidate. Psychopharmacology 57:83–87
Wechsler D (1955) Manual for the Wechsler adult intelligence scale. Psychological Corporation, New York
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Huey, L.Y., Janowsky, D.S., Judd, L.L. et al. Effects of lithium carbonate on methylphenidate-induced mood, behavior, and cognitive processes. Psychopharmacology 73, 161–164 (1981). https://doi.org/10.1007/BF00429209
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DOI: https://doi.org/10.1007/BF00429209