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Differential antagonism by the anticholinergic dexetimide of inhibitory effects of haloperidol and fentanyl on brain self-stimulation

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Abstract

Haloperidol (0.08 mg/kg) or fentanyl (0.16 mg/kg) injected subcutaneously suppressed bar-pressing for brain-stimulation in rats, implanted with electrodes in the lateral hypothalamic area of the medial forebrain bundle. Increasing doses: 0.04, 0.16, 0.63 and 2.50 mg/kg of the central anticholinergic dexetimide gradually antagonized the haloperidol effects. The highest dose of dexetimide did not reduce the fentanyl-induced inhibition. The results, together with a literature survey on the anticholinergic effects on neuroleptic-induced catalepsy and inhibition of avoidance behavior, are related to biochemical findings and clinical effects.

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Authors and Affiliations

  1. Department of Pharmacology, Janssen Pharmaceutica, Research Laboratoria, Beerse, Belgium

    Albert Wauquier, Carlos J. E. Niemegeers & Harbans Lal

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  1. Albert Wauquier
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  2. Carlos J. E. Niemegeers
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  3. Harbans Lal
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Visiting pharmacologist from Department of Pharmacology and Psychology, University of Rhode Island, Kingston, R.I., U.S.A.

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Wauquier, A., Niemegeers, C.J.E. & Lal, H. Differential antagonism by the anticholinergic dexetimide of inhibitory effects of haloperidol and fentanyl on brain self-stimulation. Psychopharmacologia 41, 229–235 (1975). https://doi.org/10.1007/BF00428929

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  • DOI: https://doi.org/10.1007/BF00428929

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