Abstract
Concurrent administration of cimetidine for 4 days to eight patients taking maintenance doses of desipramine led to significant elevations of desipramine (P<0.001) and its hydroxylated metabolite 2-hydroxydesipramine (P<0.001). The mean increase in desipramine plasma levels was 51% and that for 2-hydroxydesipramine was 46%. The present results suggest that tricyclic antidepressant plasma level monitoring might be indicated for certain patients taking concurrent cimetidine and desipramine.
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Amsterdam, J.D., Brunswick, D.J., Potter, L. et al. Cimetidine-induced alterations in desipramine plasma concentrations. Psychopharmacology 83, 373–375 (1984). https://doi.org/10.1007/BF00428548
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DOI: https://doi.org/10.1007/BF00428548