Abstract
Healthy volunteers received single oral or intravenous doses of d-amphetamine sulphate (15 mg) and placebo in a double blind randomized design. Peak velocity of horizontal saccadic eye movements, saccade duration, saccade reaction time and smooth pursuit velocity were measured at intervals up to 1 h (IV) and 6 h (oral) after drug administration.
Amphetamine produced no significant effect on saccadic and smooth-pursuit eye movements after oral administration. However, intravenous amphetamine abolished the effect of fatigue on saccadic movements and significantly (P<0.01) shortened saccadic reaction time.
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Tedeschi, G., Bittencourt, P.R.M., Smith, A.T. et al. Effect of amphetamine on saccadic and smooth pursuit eye movements. Psychopharmacology 79, 190–192 (1983). https://doi.org/10.1007/BF00427810
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DOI: https://doi.org/10.1007/BF00427810