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Lithium effects on rat brain glucose metabolism in long-term lithium-treated rats studied in vivo

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Abstract

The time course of lithium effects on several brain energy metabolites has been investigated in rats. The rats were injected once daily with lithium chloride and killed by freezing in liquid nitrogen 1–8 h after the last injection.

The effect of lithium was most marked in the period in which the brain lithium concentration was increasing, whereas the effect was wearing off when the brain lithium concentration had stabilized, even though the lithium concentration was higher.

These results led to the hypothesis that the effect of lithium on several parameters depends on the increase in lithium concentration following the administration of lithium, rather than on the absolute concentration of lithium.

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References

  • Bech, P., Vendsborg, P. B., Rafaelsen, O. J.: Lithium maintenance treatment of manic-melancholic patients: its role in the daily routine. Acta Psychiatr. Scand. 53, 70–81 (1976)

    Google Scholar 

  • Berl, S., Clarke, D. D.: Effects of lithium on the metabolism in brain of glutamate, glutamine, aspartate and GABA from (1-14C) acetat in vitro. Brain Res. 36, 203–213 (1972)

    Google Scholar 

  • Bhattacharya, G.: Influence of ions on the uptake of glucose and on the effect of insulin on it by rat diaphragm. Nature 183, 324–325 (1959)

    Google Scholar 

  • Bhattacharya, G.: Influence of lithium on glucose metabolism in rat and rabbits. Biochem. Biophys. Acta 93, 644–646 (1964)

    Google Scholar 

  • Clausen, T.: The ‘insulin-like’ effect of lithium. Biochem. Biophys. Acta 150, 66–72 (1968)

    Google Scholar 

  • DeFeudis, F. V., Delgado, J. M. R.: Effects of lithium on amino-acids in mouse brain in vitro. Nature 225, 749–750 (1970)

    Google Scholar 

  • Forn, I., Valdecasas, F. G.: Effects of lithium on brain adenyl cyclase activity. Biochem. Pharmacol. 20, 2773–2779 (1971)

    Google Scholar 

  • Gottesfeld, Z., Ebstein, B. S., Samuel, D.: Effects of lithium on concentrations of glutamate and GABA levels in amygdala and hypothalamus of rat. Nature [New Biol.] 234, 124–125 (1971)

    Google Scholar 

  • Gottesfeld, Z.: Effects of lithium and other alkali metals on brain chemistry and behaviour. Psychopharmacologia (Berl.) 45, 239–249 (1976)

    Google Scholar 

  • Knapp, S., Mandell, A. J.: Effects of lithium chloride on parameters of biosynthetic capacity for 5-hydroxy-tryptamine in rat brain. J. Pharmacol. Exp. Ther. 193, 812–823 (1975)

    Google Scholar 

  • Kohn, P. G., Clausen, T.: The relationship between the transport of glucose and cations across cell membranes in isolated tissue. Biochem. Biophys. Acta 225, 798–814 (1972)

    Google Scholar 

  • Lowry, O. H., Passoneau, J. V.: A flexible system of enzymatic analysis. New York: Academic Press 1972

    Google Scholar 

  • McIlwain, H., Bachelard, H. S.: Biochemistry of the central nervous system. Edinburgh and London: Churchill Livingstone 1971

    Google Scholar 

  • Mellerup, E. T., Lauritsen, B. J., Dam, H., Rafaelsen, O. J.: Lithium effects on diurnal rhythm of calcium, magnesium, and phosphate metabolism in manic-melancholic disorders. Acta Psychiatr. Scand. 53, 360–370 (1976)

    Google Scholar 

  • Olesen, O. V., Schou, M., Thomsen, K.: Administration of lithium to rats by different routes. Neuropsychobiology 2, 134–138 (1976)

    Google Scholar 

  • Plenge, P., Mellerup, E. T., Rafaelsen, O. J.: Lithium action on glycogen synthesis in rat brain, liver and diaphragm. J. Psychiatr. Res. 8, 29–36 (1970)

    Google Scholar 

  • Plenge, P. K., Mellerup, E. T., Rafaelsen, O. J.: Weight gain in lithium treated rats. Int. Pharmacopsychiatry 8, 234–238 (1973)

    Google Scholar 

  • Plenge, P.: Acute lithium effects on rat brain glucose metabolism-in vivo. Int. Pharmacopsychiatry 11, 84–92 (1976)

    Google Scholar 

  • Stefanini, E., Argiolas, A., Gessa, G. L., Fadda, F.: Effect of lithium on dopamine uptake by brain synaptosomes. J. Neurochem. 27, 1237–1239 (1976)

    Google Scholar 

  • Stevenson, G. H., Geoghegan, J. J.: Prophylactic electroshock. Am. J. Psychiatry 107, 743–748 (1951)

    Google Scholar 

  • Thomsen, K.: The effect of sodium chloride on kidney function in rats with lithium intoxication. Acta Pharmacol. Toxicol. (Kbh.) 33, 92–102 (1973)

    Google Scholar 

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  1. Psykokemisk Institut, Københavns Universitet, Rigshospitalet, Blesdamsvej 9, DK-2100, København Ø, Denmark

    Per Plenge

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  1. Per Plenge
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Plenge, P. Lithium effects on rat brain glucose metabolism in long-term lithium-treated rats studied in vivo. Psychopharmacology 58, 317–322 (1978). https://doi.org/10.1007/BF00427398

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  • DOI: https://doi.org/10.1007/BF00427398

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