Abstract
Ten days after administration of 5,6-dihydroxytryptamine, which causes degeneration of central serotoninergic neurons, the depressive behavioral effects of PGF2α and PGE2 were evidently inhibited. Central chemical serotoninectomy abolished the hyperthermic and hypertensive effects of PGF2α, but only slightly affected those of PGE2. It is concluded that serotoninergic neurons mediate the depressive behavioral action of both PGF2α and PGE2. They also mediate the hyperthermic and hypertensive action of PGF2α but not of PGE2. This suggests that these prostaglandins have different central modes of action.
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Axelrod, J.: Regulation of the synthesis, release, and action of catecholamine neurotransmitters. First European Symposium on Hormones and Cell Regulation Dumont, Nunez, eds., pp. 137–155. Elsevier, North Holland 1977
Baumgarten, H. B., Lachenmayer, L., Björklund, A., Nobin, A., Rosengarten, E.: Long-term recovery of serotonin concentrations in the rat CNS following 5,6-dihydroxytryptamine. Life Sci. 12, 357–364 (1973)
Björklund, A., Nobin, A., Stenevi, U.: Effects of 5,6-dihydroxytryptamine on nerve terminal serotonin and serotonin uptake in the rat brain. Brain Res. 53, 117–127 (1973)
Bloom, F. E.: Amine receptors in CNS. I. Norepinephrine. In: Handbook of psychopharmacology, Vol. 6. Biogenic amine receptors. L. L. Iversen, S. D. Iversen, S. H. Snyder, eds. pp. 1–22. New York, London: Plenum 1975
Breese, G. R., Cooper, B. R., Grant, L. D., Smith, R. D.: Biochemical and behavioral alterations following 5,6-dihydroxytryptamine administration into brain. Neuropharmacology 13, 177–187 (1974)
Brody, M. J., Kadowitz, P. J.: Prostaglandins as modulators of the autonomic nervous system. Fed. Proc. 33, 48–60 (1974)
Brus, R., Herman, Z. S., Szkilnik, R., Zabawska, J., Bonczek, A., Zieliński, M., Opiełka, L.: The influence of biogenic amines and cyclic nucleotides on rat behavior after the chemical serotoninectomy of the central nervous system. Pol. J. Pharmacol. Pharm. 30, 323–334 (1978)
Coceani, F.: Prostaglandins and the central nervous system. Arch. Int. Med. 133, 119–129 (1974)
Feldberg, W., Saxena, P. N.: Fever produced by prostaglandin E1. J. Physiol. (Lond.) 217, 547–566 (1971)
File, S. E., Pope, J. H.: The action of chlorpromazine on exploration in pairs of rats. Psyochpharmacologia 37, 249–254 (1974)
Green, R. A., Gillin, J. C., Wyatt, R. J.: The inhibitor effect of intraventricular administration of serotonin on spontaneous motor activity of rats. Psychopharmacology 51, 81–84 (1976)
Hedqvist, P.: Prostaglandin as a tool for local control of transmitter release from sympathetic nerves. Brain Res. 62, 483–488 (1973)
Hedqvist, P., Brundin, J.: Inhibition by prostaglandin E1 of noradrenaline release and of effector responses to nerve stimulation in the cat spleen. Life Sci. 8, 389–395 (1969)
Herman, Z. S.: The effects of noradrenaline on rat's behaviour. Psychopharmacologia 16, 369–374 (1970)
Herman, Z. S.: Behavioral changes induced in conscious mice by intracerebroventricular injection of catecholamines, acetylcholine and 5-hydroxytryptamine. Br. J. Pharmacol. 55, 351–358 (1975)
Herman, Z. S., Bonczek, A.: Model of central chemical “serotoninectomy” in mice. Pharmacology 17, 8–14 (1978)
Herman, Z. S., Kmieciak-Kolada, K., Wolny, H. L., Slomińska-Żurek, J., Bonczek, A.: Central effects of prostaglandins F2α and E1. Pol. J. Pharmacol. Pharm. 28, 411–421 (1976)
Horton, E. W.: Actions of prostaglandins E1, E2 and E3 on the central nervous system. Br. J. Pharmacol. 22, 189–192 (1964)
Janssen, P. A. J., Jageneau, A. H., Schellekens, K. H. L.: Chemistry and pharmacology of compounds related to 4-/4-hydroxy-4-phenylpiperidino-butyrohenone. Part IV. Influence of haloperidol (R 1625) and chlorpromazine on the behaviour of rats in unfamiliar “open field” situation. Psychopharmacologia 1, 389–392 (1960)
Jell, R. M., Sweatman, P.: Prostaglandin-sensitive neurones in cat hypothalamus: relation to thermoregulation and to biogenic amines. Can. J. Phsiol. Pharmacol. 55, 560–567 (1977)
Komiskey, H. L., Rudy, T. A.: The involvement of methysergide-sensitive receptors and prostaglandins in the hyperthermia evoked by 5-HT in the cat Res. Commun. Chem. Pathol. Pharmacol. 11, 195–208 (1975)
Laburn, H., Woolf, C. J., Willies, G. H., Rosendorff, C.: Pyrogen and prostaglandin fever in the rabbit. II: Effects of noradrenaline depletion and adrenergic receptor blockade. Neuropharmacology 14, 405–411 (1975)
Milon, A. S., Wendlandt, S.: A possible role for prostaglandin E1 as a modulator for temperature regulation in the nervous system of the cat. J. Physiol. Lond.) 27, 76–77P (1970)
Myers, R. D., Rudy, T. A., Yaksh, T. L.: Fever produced by endotoxin injected into the hypothalamus of the monkey and its antagonism by salicylate. J Physiol. (Lond.) 243, 167–193 (1974)
Nakamura, K., Thoenen, H.: Increased irritability: A permanent behavior change induced in the rat by intraventricular administration of 6-hydroxydopamine. Psychopharmacologia 24, 359–372 (1972)
Poddubiuk, Z. M.: A comparison of the central actions of prostaglandins A1, E1, E2, F1α, and F2α in the rat. Part I. Psychopharmacology 50, 89–94 (1976)
Richardson, J. S., Cowan, N., Hartman, R., Jacobowitz, D. M.: On the behavioral and neurochemical actions of 6-hydroxydopa and 5,6-dihydroxytryptamine in rats. Res. Commun. Chem. Pathol. Pharmacol. 8, 29–45 (1974)
Rinchuse, D. J., Deuben, R. R.: Central mediated pressor effect by prostaglandins in the rat. Prostaglandins 11, 523–530 (1976)
Rudy, T. A., Viswanathan, C. T.: Effect of central cholinergic blockade on the hyperthermia evoked by prostaglandin E1 injected into the rostral hypothalamus of the rat. Can. J. Physiol. Pharmacol. 53, 321–324 (1975)
Samuelsson, B.: Identification of a smooth muscle-stimulating factor in bovine brain. Biochim. Biophys. Acta 84, 218–219 (1964)
Veale, W. L., Whishaw, I. Q.: Body temperature responses at different ambient temperatures following injections of prostaglandin E1 and noradrenaline into brain. Pharmacol. Biochem. Behav. 4, 143–150 (1976)
Warbritton, J. D. III., Stewart, R. M., Baldessarini, R. J.: Decreased locomotor activity and attenuation of amphetamine hyperactivity with intraventricular infusion of serotonin in the rat. Brain Res. 143, 373–382 (1978)
Westfall, T. C., Kitay, D.: The effect of prostaglandins on the release of [3H]dopamine from superfused slices of rat striatum following electrical stimulation. Proc. Soc. Exp. Biol. Med. 155, 305–307 (1977)
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Brus, R., Herman, Z.S., Szkilnik, R. et al. Mediation of central prostaglandin effects by serotoninergic neurons. Psychopharmacology 64, 113–120 (1979). https://doi.org/10.1007/BF00427355
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DOI: https://doi.org/10.1007/BF00427355