Abstract
Two biochemical distinct groups of manic depressive patients seem to be present. One group showed a normal pattern of plasma amino acids and was resistant to oral tryptophan medication. Another group, characterized by a relative deficiency of tryptophan in plasma as measured by the ratio of total plasma tryptophan to competing amino acids, responded readily to tryptophan treatment. No significant differences could be demonstrated in the free tryptophan, total tryptophan, percentage of free tryptophan or kynurenine in the plasma between patients and controls. The findings are discussed in view of changes in the transport conditions of tryptophan from plasma into the brain.
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Armstrong, M. D., Stave, U.: A study of plasma free amino acid levels. II. Normal values for children and adults. Metabolism 22, 561–569 (1973)
Aschroft, G. W., Blackburn, I. M., Eccleston, D., Glen, A. I. M., Hartley, W., Kinloch, N. E., Lonergan, M., Murray, L. G., Pullar, I. A.: Changes on recovery in the concentrations of tryptophan and the biogenic amine metabolites in the cerebrospinal fluid of patients with affective illness. Psychol. Med. 3, 319–325 (1973)
Beigel, A., Murphy, D. L., Bunney, W. E., Jr.: The manic-state rating scale. Arch. gen. Psychiat. 25, 256–262 (1971)
Benkert, O., Renz, A., Marano, C., Matussek, N.: Altered tyrosine daytime plasma levels in endogenous depressive patients. Arch. gen. Psychiat. 25, 359–363 (1971)
Biggio, G., Fadda, F., Fanni, P., Tagliamonte, A., Gessa, G. L.: Rapid depletion of serum tryptophan, brain tryptophan, serotonin and 5-hydroxyindoleacetic acid by a tryptophan-free diet. Life Sci. 14, 1321–1329 (1974)
Birkmayer, W., Linauer, W.: Störung des Tyrosin- und Tryptophanmetabolismus bei Depression. Arch. Psychiat. Nervenkr. 213, 377–387 (1970)
Broadhurst, A. D.: L-tryptophan versus E.C.T. Lancet 1970I, 1392–1393
Carroll, B. J., Wowbray, R. M., Davies, B.: Sequential comparison of l-tryptophan with E.C.T. in severe depression. Lancet 1970I, 967–969
Coon, M. J., Robinson, W. G., Bachhawat, B. K.: Enzymatic studies on the biological degradation of the branched chain amino acids. In: Amino acid metabolism, W. D. McElroy and H. B. Glass, eds., pp. 431–441. Baltimore: The John Hopkins Press 1955
Coppen, A.: Serotonin in affective disorders. In: Factors in depression, N. S. Kline, ed., pp. 33–44. New York: Raven Press 1974
Coppen, A., Brooksbank, B. W. L., Eccleston, E., Peet, M., White, S. G.: Tryptophan metabolism in depressive illness. Psychol. Med. 4, 164–173 (1974)
Coppen, A., Brooksbank, B. W. L., Peet, M.: Tryptophan concentration in the cerebrospinal fluid of depressive patients. Lancet 1972aI, 1393
Coppen, A., Eccleston, E. G., Peet, M.: Total and free tryptophan concentration in the plasma of depressive patients. Lancet 1972bII, 1415–1416
Coppen, A., Eccleston, E. G., Peet, M.: Total and free tryptophan concentration in the plasma of depressive patients. Lancet 1973II, 60–63
Coppen, A., Shaw, D. M., Farrell, J. P.: Potentiation of the antidepressive effect of a monoamine-oxidase inhibitor by tryptophan. Lancet 1963I, 79–81
Coppen, A., Shaw, D. M., Herzberg, B., Maggs, R.: Tryptophan in the treatment of depression. Lancet 1967II, 1178–1180
Curzon, G., Bridges, P. K.: Tryptophan metabolism in depression. J. Neurol. Neurosurg. Psychiat. 33, 698–704 (1970)
Curzon, G., Kantamaneni, B. D., Winch, J., Rojas-Buoeno, A., Murray-Lyon, I. M., Williams, R.: Plasma and brain tryptophan changes in experimental acute hepatic failure. J. Neurochem. 21, 137–145 (1973)
Daniel, P. M., Love, E. R., Moorhouse, S. R., Pratt, O. E.: Amino-acids, insulin, and hepatic coma. Lancet 1975II, 179–180
Denckla, W. D., Dewey, H. K.: The determination of tryptophan in plasma, liver and urine. J. Lab. clin. Med. 69, 160–169 (1967)
Felig, P., Owen, O. E., Wahren, J., Cahill, G. F.: Amino acid metabolism during prolonged starvation. J. clin. Invest. 48, 584–594 (1969)
Felig, P., Wahren, J., Ahlborg, G.: Uptake of individual amino acids by the human brain. Proc. Soc. exp. Biol. (N.Y.) 142, 230–231 (1973)
Fernstrom, J. D., Larin, F., Wurtman, R. J.: Correlations between brain tryptophan and plasma neutral amino acid levels following food consumption in rats. Life Sci. 13, 517–524 (1973)
Fernstrom, J. D., Wurtman, R. J.: Brain serotonin content: physiological dependence on plasma tryptophan levels. Science 173, 149–152 (1971)
Fernstrom, J. D., Wurtman, R. J.: Brain serotonin content: physiological regulation by plasma neutral amino acids. Science 178, 414–416 (1972)
Frazer, A., Pandey, G. N., Mendels, J.: Metabolism of tryptophan in depressive disease. Arch. gen. Psychiat. 29, 528–535 (1973)
Gessa, G. L., Biggio, G., Fadda, F., Corsini, G. U., Tagliamonte, A.: Effect of the oral administration of tryptophan-free amino acid mixtures on serum tryptophan, brain tryptophan and serotonin metabolism. J. Neurochem. 22, 869–870 (1974)
Gopalan, C., Srinkantia, S. G.: Leucine and pellagra. Lancet 1960I, 954–957
Green, A. R., Curzon, G.: The effect of tryptophan metabolites on brain 5-hydroxytryptamine metabolism. Biochem. Pharmacol. 19, 2061–2068 (1970)
Hamilton, M.: A rating scale for depression. J. Neurol. Neurosurg. Psychiat. 23, 56–62 (1960)
Hartmann, E., Cravens, J., List, S.: Hypnotic effects of l-tryptophan. Arch. gen. Psychiat. 31, 394–397 (1974)
Kiely, M., Sourkes, T. L.: Transport of l-tryptophan into slices of rat cerebral cortex. J. Neurochem. 19, 2863–2872 (1972)
Knott, P. J., Curzon, G.: Free tryptophan in plasma and brain tryptophan metabolism. Nature (Lond.) 239, 452–453 (1972)
Lapin, I. P.: Kynurenines as probable participants of depression. Pharmakopsychiat. 6, 273–279 (1973)
Lapin, I. P., Oxenkrug, G. F.: Intensification of the central serotoninergic processes as a possible determinant of the thymoleptic effect. Lancet 1969I, 132–136
Lehman, J.: Mental and neuromuscular symptoms in tryptophan deficiency. Acta psychiat. scand., Suppl. 237 (1972)
Madras, B. K., Cohen, E. L., Messing, R., Munro, H. N., Wurtman, R. J.: Relevance of free tryptophan in serum to tissue tryptophan concentrations. Metabolism 23, 1107–1116 (1974)
McKean, C. M., Boggs, D. E., Peterson, N. A.: The influence of high phenylalanine and tyrosine on the concentrations of essential amino acids in brain. J. Neurochem. 15, 235–241 (1968)
McMenamy, R. H., Oncley, J. L.: The specific binding of l-tryptophan to serum albumin. J. biol. Chem. 233, 1436–1447 (1958)
McMenamy, R. H., Shoemaker, W. C., Richmond, J. E., Elwyn, D.: Uptake and metabolism of amino acids by the dog liver perfused in situ. Amer. J. Physiol. 202, 407–414 (1962)
Miller, L. L.: The role of the liver and the non-hepatic tissues in the regulation of free amino acid levels in the blood. In: Amino acid pools, J. T. Holden, ed., pp. 708–721. Amsterdam: Elsevier Publ. Comp. 1962
Moir, A. T. B., Eccleston, D.: The effects of precursor loading in the cerebral metabolism of 5-hydroxyindoles. J. Neurochem. 15, 1093–1108 (1968)
Munro, H. N., Fernstrom, J. D., Wurtman, R. J.: Plasma neutral aminoacids and tryptophan in cirrhosis. Lancet 1975aII, 419
Munro, H. N., Fernstrom, J. D., Wurtman, R. J.: Insulin, plasma aminoacid imbalance, and hepatic coma. Lancet 1975bI, 722–724
Murphy, D. L., Baker, M., Goodwin, F. K., Miller, H., Kotin, J., Bunney, W. E., Jr.: L-tryptophan in affective disorders: Indoleamine changes and differential clinical effects. Psychopharmacologia (Berl.) 34, 11–20 (1974)
Murphy, D. L., Baker, M., Kotin, J., Bunney, W. E., Jr.: Behavioral and metabolic effects of l-tryptophan in unipolar depressed patients. In: Serotonin and behaviour, J. Barchas and E. Usdin, eds., pp. 529–537. New York: Academic Press 1972
Møller, S. E.: A method for the separation of plasma amino acids by ion-exchange chromatography combined with a semi-automatic computation of plasma amino acid concentrations. J. Chromatogr. 104, 63–72 (1975)
Møller, S. E., Kirk, L., Fremming, K. H.: The plasma amino acid pattern by manic depressive patients. Nord. psykiat. T. 29, 461–462 (1975)
Oldendorf, W. H.: Saturation of blood brain barrier transport of amino acids in phenylketonuria. Arch. Neurol. (Chic.) 28, 45–48 (1973)
Pare, C. M. B.: Potentiation of monoamine-oxidase inhibitors by tryptophan. Lancet 1963II, 527–528
Rafaelsen, O. J.: Manic-depressive psychosis or manic-melancholic mode. Dan. med. Bull. 21, 81–87 (1974)
Ramanamurthy, P. S. V., Srikantia, S. G.: Effects of leucine on brain serotonin. J. Neurochem. 17, 27–37 (1970)
Rees, J. R., Allsopp, M. N. E., Hullin, R. P.: Plasma concentrations of tryptophan and other amino acids in manic-depressive patients. Psychol. Med. 4, 334–337 (1974)
Swenseid, M. E., Yamada, C., Vinyard, E., Figuerosa, W. G., Drenick, E. J.: Plasma amino acid levels in subjects fed isonitrogenous diets containing different proportions of fat and carbohydrate. Amer. J. clin. Nutr. 20, 52–55 (1967)
Tagliamonte, A., Biggio, G., Vargin, L., Gessa, G. L.: Free tryptophan in serum controls brain tryptophan level and serotonin synthesis. Life Sci. 12, 277–287 (1973)
van Praag, H. M., Korf, J.: Serotonin metabolism in depression: clinical application of the probenecid test. Int. Pharmacopsychiat. 9, 35–51 (1974)
Wilson, I. C., Prange, A. J., Jr.: Tryptophan in mania: Theory of affective disorders. Psychopharmacologia (Berl.) 26 (Suppl), 76 (1972)
Wurtman, R. J., Rose, C. M., Chou, C., Larin, F. F.: Daily rhytms in the concentrations of various amino acids in human plasma. New Engl. J. Med. 279, 171–175 (1968)
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Møller, S.E., Kirk, L. & Fremming, K.H. Plasma amino acids as an index for subgroups in manic depressive psychosis: Correlation to effect of tryptophan. Psychopharmacology 49, 205–213 (1976). https://doi.org/10.1007/BF00427292
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DOI: https://doi.org/10.1007/BF00427292