Abstract
Previous studies in our laboratory have demonstrated that inhibition of prostaglandin biosynthesis through pretreatment with aspirin and other prostaglandin synthetase inhibitors (PGSI) significantly reduces CNS sensitivity to a hypnotic dose of ethanol. Indomethacin, a potent PGSI, was administered to male LS, SS, and HS/Ibg mice (65±10 days of age) 15 min prior to administration of a hypnotic dose of ethanol or pentobarbital. Doses of indomethacin used were identical to those previously reported as optimally antogonizing ethanol-induced sleep. Another group received a vehicle-control injection, while a third group also received a control injection, but were placed in a incubator maintained at 30±1°C. Body temperatures were recorded periodically for several hours. Both indomethacin and incubation significantly reduced hypothermia induced by ethanol and pentobarbital. Incubation increased sleep time after ethanol, but did not affect pentobarbital sleep time. These results suggest that the hypnotic and hypothermic effects of ethanol, although possibly mediated through prostaglandins, apparently are not causally linked.
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References
Bergstrom S, Farnebo LO, Fuxe K (1973) Effect of prostaglandin E2 on central and peripheral catecholamine neurons. Eur J Pharmacol 21:362–368
Coceani F (1974) Prostaglandins and the central nervous system. Arch Int Med Exp 133:119–129
Collier HOJ, McDonald-Gibson WJ, Saeed SA (1976) Stimulation of prostaglandin synthesis by drugs: Effects in vitro of some drugs affecting gut function. Br J Pharmacol 58:193–199
Feldberg W, Milton AS (1973) Prostaglandins in fever. In: Schonbaum E, Lomax P (eds) The pharmacology of temperature regulation. Karger, Basel, pp 302–310
George FR, Collins AC (1979a) Prostaglandin inhibition differentially blocks ethanol-induced depression in LS and SS mice. Bull Colo Wyo Acad Sci 11:64–65
George FR, Collins AC (1979b) Prostaglandin synthetase inhibitors antagonize the depressant effects of ethanol. Pharmacol Biochem Behav 10:865–869
Hedqvist P (1970) Studies on the effect of prostaglandins E1 and E2 on the sympathetic neuromuscular transmission in some animal tissues. Acta Physiol Scand (Suppl) 345
Kakihana R (1976) Adrenocortical function in mice selectively bred for different sensitivity to ethanol. Life Sci 18:1131–1138
Kuehl Jr FA, Cirillo VJ, Humes JL (1973) The regulatory role of the prostglandins on the cyclic 3′,5′-AMP system. In: Bergstrom S (ed) Advances in the biosciences, vol 9. Pergamon Press, New York, pp 155–172
Lin MT (1979) Systemic administration of prostaglandin E1 produces hypothermic effects in unanesthetized rats. J Pharmacol Exp Ther 209:349–351
Pohorecky LA, Brick J, Sun JY (1976) Serotonergic involvement in the effect of ethanol on body temperature in rats. J Pharm Pharmacol 28:157–159
Ritzmann RF, Tabakoff B (1976) Body temperature in mice: A quantitative measure of alcohol tolerance and physical dependence. J Pharmacol Exp Ther 199:158–170
Rotrosen J, Mandio D, Segarnick D, Traficante LJ, Gershon S (1980) Ethanol and prostaglandin E1: Biochemical and behavioral interactions. Life Sci 26:1867–1876
Starke K (1977) Regulation of noradrenaline release by presynaptic receptor systems. Rev Physiol Biochem Pharmacol 77:1–124
Veale WL, Whishaw IQ (1976) Body temperature responses at different ambient temperatures following injections of prostaglandin E1 and noradrenaline into the brain. Pharmacol Biochem Behav 4:143–150
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George, F.R., Jackson, S.J. & Collins, A.C. Prostaglandin synthetase inhibitors antagonize hypothermia induced by sedative hypnotics. Psychopharmacology 74, 241–244 (1981). https://doi.org/10.1007/BF00427102
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DOI: https://doi.org/10.1007/BF00427102