Skip to main content
SpringerLink
Log in

Lysergic acid diethylamide antagonizes shaking induced in rats by five chemically different compounds

  • Published:
Psychopharmacology Aims and scope Submit manuscript

Abstract

Thyrotropin-releasing hormone (TRH), sodium valproate, AG-3-5 (1-[2-hydroxyphenyl]-4-[3-nitrophenyl]-1,2,3,6-tetrahydropyrimidine-2-one), RX336-M (7,8-dihydro-5′, 6′-dimethylcyclohex-5′-eno-1′,2′,8′,14 codeinone), and Sgd 8473 (α-[(4-chlorobenzylideneamino)-oxy]-isobutyric acid) each induced repetitive shaking of the body of rats after intraperitoneal injection. This action of the five diverse chemicals appears to be subserved by a common pharmacological component, because pretreatment with d-lysergic acid diethylamide (0.03–1.0 mg kg-1, s.c.) attenuated the shaking behavior in a dose-related manner, and cross tolerance was found between RX 336-M and TRH, sodium valproate, and AG-3-5.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Aghajanian, G. K.: LSD and 2-brom-LSD: comparison of effects on serotonergic neurones and on neurones in two serotonergic projection areas, the ventral lateral geniculate and amygdala. Neuropharmacology 15, 521–528 (1976)

    Google Scholar 

  • Andén, N.-E., Corrodi, H., Fuxe, K., Hökfelt, T.: Evidence for a central 5-hydroxy-tryptamine receptor stimulation by lysergic acid diethylamide. Br. J. Pharmacol. 34, 1–7 (1968)

    Google Scholar 

  • Ary, M., Cox, B., Lomax, P.: Dopaminergic mechanisms in precipitated withdrawal in morphine-dependent rats. J. Pharmacol. Exp. Ther. 200, 271–276 (1977)

    Google Scholar 

  • Bläsig, J., Herz, A., Reinhold, K., Zieglgänsberger, S.: Development of physical dependence on morphine in respect to time and dosage and quantification of the precipitated withdrawal syndrome in rats. Psychopharmacologia (Berl.) 33, 19–38 (1973)

    Google Scholar 

  • Bloom, F., Segal, D., Ling, N., Guillemin, R.: Endorphins: profound behavioral effects in rats suggest new etiological factors in mental illness. Science 194, 630–632 (1976)

    Google Scholar 

  • Burford, R. G., Chappel, C. I.: “Wet dog shake” induction in rats by a novel compound AG-3-5. Abstract, 5th Int. Congr. Pharmacol. 33 (1972)

  • Costall, B., Kelly, D. M., Naylor, R. J.: Nomifensine: a potent dopaminergic agonist of Antiparkinson potential. Psychopharmacologia (Berl.) 41, 153–164 (1975)

    Google Scholar 

  • Costall, B., Naylor, R. J.: The role of the raphé and extrapyramidal nuclei in the stereotyped and circling responses to quipazine. J. Pharm. Pharmacol. 27, 368–371 (1975)

    Google Scholar 

  • Cowan, A., Macfarlane, I. R.: Effect of morphine antagonists on drug-induced hypothermia in mice and rats. Psychopharmacologia (Berl.) 45, 277–282 (1976)

    Google Scholar 

  • Dixon, A. K.: Evidence of catacholamine mediation in the “aberrant” behaviour induced by lysergic acid diethylamide (LSD) in the rat. Experientia (Basel) 24, 743–747 (1968)

    Google Scholar 

  • Francis, D. L., Roy, A. C., Collier, H. O. J.: Morphine abstinence and quasi-abstinence effects after phosphodiesterase inhibitors and naloxone. Life Sci. 16, 1901–1906 (1975)

    Google Scholar 

  • Gispen, W. H., Wiegant, V. M., Bradbury, A. F., Hulme, E. C., Smyth, D. G., Snell, C. R., deWied, D.: Induction of excessive grooming in the rat by fragments of lipotropin. Nature (Lond.) 264, 794–795 (1976)

    Google Scholar 

  • Gispen, W. H., Wiegant, V. M., Greven, H. M., deWied, D.: The induction of excessive grooming in the rat by intraventricular application of peptides derived from ACTH: structure-activity studies. Life Sci. 17, 645–652 (1975)

    Google Scholar 

  • Jacoby, J. H., Howd, R. A., Levin, M. S., Wurtman, R. J.: Mechanisms by which quipazine, a putative serotonin receptor agonist, alters brain 5-hydroxyindole metabolism. Neuropharmacology 15, 529–534 (1976)

    Google Scholar 

  • Jahn, U., Mixich, G.: Benzylidenaminooxy-Carbonsäure—Derivate als Auslöser von “wet-dog shake” — Verhalten bei normalen Ratten. Psychopharmacologia (Berl.) 46, 191–196 (1976)

    Google Scholar 

  • Kelly, P. H., Iversen, L. L.: LSD as an agonist at mesolimbic dopamine receptors. Psychopharmacologia (Berl.) 45, 221–224 (1975)

    Google Scholar 

  • Lance, J. W., Anthony, W.: Sodium valproate and clonazepam in the treatment of intractable epilepsy. Arch. Neurol. (Chic.) 34, 14–17 (1977)

    Google Scholar 

  • Leybin, L., Pinsky, C., LaBella, F. S., Havlicek, V., Rezek, M.: Intraventricular Met5-enkephalin causes unexpected lowering of pain threshold and narcotic withdrawal signs in rats. Nature (Lond.) 264, 458–459 (1976)

    Google Scholar 

  • Martin, W. R., Eades, C. G., Thompson, J. A., Huppler, R. E., Gilbert, P. E.: The effects of morphine-and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J. Pharmacol. Exp. Ther. 197, 517–532 (1976a)

    Google Scholar 

  • Martin, W. R., Sloan, J. W., Buchwald, W. F.: In vitro evidence of brain k receptors. Pharmacologist 18, 120 (1976b)

    Google Scholar 

  • Martin, W. R., Wikler, A., Eades, C. G., Pescor, F. T.: Tolerance to and physical dependence on morphine in rats. Psychopharmacologia (Berl.) 4, 247–260 (1963)

    Google Scholar 

  • Mogilnicka, E., Klimek, V., Golemboiwska-Nikitin, K.: Effect of nomifensine on central 5-hydroxytryptamine neurons. Naunyn Schmiedebergs Arch. Pharmacol. [Suppl.] 294, R. 16 (1976)

    Google Scholar 

  • Nichols, D. E.: Structure correlation between apomorphine and LSD: involvement of dopamine as well as serotonin in the actions of hallucinogens. J. Theor. Biol. 59, 167–177 (1976)

    Google Scholar 

  • Pieri, M., Pieri, L., Saner, A., DaPrada, M., Haefely, W.: A comparison of drug-induced rotation in rats lesioned in the medial forebrain bundle with 5,6-dihydroxytryptamine or 6-hydroxydopamine. Arch. Int. Pharmacodyn. 217, 118–130 (1975)

    Google Scholar 

  • Pinder, R. M., Brogden, R. N., Speight, T. M., Avery, G. S.: Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy. Drugs 13, 81–102 (1977)

    Google Scholar 

  • Prange, A. J., Breese, G. R., Cott, J. M., Martin, B. R., Cooper, B. R., Wilson, I. C., Plotnikoff, N. P.: Thyrotropin-releasing hormone: antagonism of pentobarbital in rodents. Life Sci. 14, 447–455 (1974)

    Google Scholar 

  • Trulson, M. E., Ross, C. A., Jacobs, B. L.: Behavioral evidence for the stimulation of CNS serotonin receptors by high doses of LSD. Psychopharmacol. Commun. 2, 149–164 (1976)

    Google Scholar 

  • Wei, E.: Chemical stimulants of shaking behaviour. J. Pharm. Pharmacol. 28, 722–724 (1976)

    Google Scholar 

  • Wei, E., Loh, H. H., Way, E. L.: Potency of the N3im-methyl analog of TRH in the induction of shaking movements in the rat. Eur. J. Pharmacol. 36, 227–229 (1976)

    Google Scholar 

  • Wei, E., Sigel, S., Loh, H. H., Way, E. L.: Thyrotropin-releasing hormone and shaking behaviour in rat. Nature (Lond.) 253, 739–740 (1975)

    Google Scholar 

  • Wikler, A., Green, P. C., Smith, H. D., Pescor, F. T.: Use of a benzimidazole derivative with potent morphine-like properties orally as a presumptive reinforcer in conditioning of drug seeking behavior in rats. Fed. Proc. 19, 22 (1960)

    Google Scholar 

Download references

Author information

Author notes

  1. Alan Cowan

    Present address: Department of Pharmacology, Temple University School of Medicine, 19140, Philadelphia, Pennsylvania, USA

Authors and Affiliations

  1. Department of Pharmacology, Reckitt & Colman, HU8 7DS, Hull, England

    Alan Cowan & Trevor Watson

Authors
  1. Alan Cowan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Trevor Watson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cowan, A., Watson, T. Lysergic acid diethylamide antagonizes shaking induced in rats by five chemically different compounds. Psychopharmacology 57, 43–46 (1978). https://doi.org/10.1007/BF00426956

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00426956

Key words

Search

Navigation