Abstract
The effect of long-term lithium carbonate treatment on parameters of immediate, short-, and long-term memory was examined in a group of bipolar affectively ill patients. The lithium treatment group recalled significantly fewer words across trials on a verbal learning task than a group of bipolar affectively ill patients receiving no medication. The ability to consistently recall material for which prior learning had been demonstrated was also decreased and accounted for most of the variance in total number of words recalled. Possible mechanisms of effect are discussed.
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References
Bajor, G. F.: Memory loss with lithium. Am. J. Psychiatry 134, 588 (1977)
Batting, W. F., Montague, W. E.: Category nouns for verbal stems in 56 categories: a replication and extension of the Connecticut category nouns. J. Exp. Psychol. 80, 1–46 (1969)
Benowitz, L., Sperry, R. W.: Amnesic effects of lithium chloride in chicks. Exp. Neurol. 40, 540–546 (1973)
Bjegovic, M., Randic, M.: Effects of lithium ions on the release of acetycholine from the cerebral cortex. Nature 230, 587–588 (1971)
Bunney, W. E., Jr., Murphy, D. L.: Neurobiological considerations on the mode of action of lithium carbonate in the treatment of affective disorders. Pharmakopsychiatr. Neuro-Psychopharmakol. 9, 142–147 (1976)
Buschke, H.: Selective reminding for analysis of memory and learning. J. Verbal Learning Verbal Behav. 12, 543–550 (1973)
Christodoulou, G. N., Sierfakas, A., Rinieris, P. M.: Side effects of lithium. Acta Psychiatr. Belg. 77, 260–266 (1977)
Craik, F., Lockhart, R. S.: Levels of processing: A framework for memory research. J. Verbal Learning Verbal Behav. 11, 671–684 (1972)
de Wied, D.: Behavioral effects of intraventricularly administered vasopressin and vasopressin fragments. Life Sci. 19, 685–690 (1976)
Flemenbaum, A.: Lithium inhibition of norepinephrine and dopamine receptors. Biol. Psychiatry 12, 563–572 (1977)
Friedman, M. J., Culver, C. M., Ferrell, R. B.: On the safety of long-term treatment with lithium. Am. J. Psychiatry 134, 1123–1126 (1977)
Gibbs, M. E., Ng, K. T.: Psychobiology of memory: Towards a model of memory formation. Biobehav. Rev. 1, 113–136 (1977)
Henry, G. M., Weingartner, H., Murphy, D. L.: Influence of affective states and psychoactive drugs on verbal learning and memory. Am. J. Psychiatry 130, 966–971 (1973)
Johnson, F. N.: The effects of lithium chloride on one-trial passive avoidance learning in rats. Br. J. Pharmacol. 56, 87–91 (1976)
Johnson, F. N., Baker, G. J.: Effects of lithium chloride on learning responses. Dis. Nerv. Syst. 33, 664–666 (1972)
Judd, L., Hubbard, B., Janowsky, D.: Effect of lithium carbonate on the cognitive functions of normal subjects. Arch. Gen. Psychiatry 34, 355–357 (1977a)
Judd, L., Hubbard, B., Janowsky, D., Huey, L. Y., Attewell, P. A.: Lithium carbonate in normal subjects. Arch. Gen. Psychiatry 34, 346–354 (1977b)
Karniol, I. G., Dalton, J., Lader, M. H.: Acute and chronic effects of lithium chloride on physiological and psychological measures in normals. Psychopharmacology 57, 289–294 (1978)
Kusumo, K. S., Vaughan, M.: Effect of lithium salts on memory. Br. J. Psychiatry 131, 453–457 (1977)
Mark, R. F., Watts, M. E.: Drug inhibition of memory formation in chickens. I. Long-term memory. Proc. R. Soc. London 178, 439–454 (1971)
McGaugh, J. L.: Drug facilitation of learning and memory. Annu. Rev. Pharmacol. 13, 229–241 (1973)
Murphy, D. L., Henry, G. M.: Catecholamines and memory: enhanced verbal learning during L-DOPA administration. Psychopharmacologia 27, 319–326 (1972)
Preodor, D., Wolpert, G. Y., Ostrow, D., Holinger, P., Wolpert, E. A.: Memory loss with lithium treatment. Am. J. Psychiatry 134, 1047–1048 (1977)
Reus, V. I., Silberman, E., Post, R. M., Weingartner, H.: d-Amphetamine: effects on memory in a depressed population. Biol. Psychiatry (in press)
Spitzer, R. L., Endicott, J., Robins, E.: Clinical criteria for psychiatric diagnosis and DSM II. Am. J. Psychiatry 132, 1186–1192 (1975)
Stefanini, E., Argiolas, A., Gessa, G. L., Fadda, F.: Effect of lithium on dopamine uptake by brain synaptosomes. J. Neurochem. 26, 1–3 (1976)
Stromgren, L. S.: The influence of depression on memory. Acta Psychiatr. Scand. 56, 109–128 (1977)
Watts, M. E., Mark, R. F.: Drug inhibition on memory formation in chickens. II. Short-term memory. Proc. R. Soc. Med. 178, 455–464 (1971)
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Reus, V.I., Targum, S.D., Weingartner, H. et al. Effect of lithium carbonate on memory processes of bipolar affectively ill patients. Psychopharmacology 63, 39–42 (1979). https://doi.org/10.1007/BF00426919
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DOI: https://doi.org/10.1007/BF00426919