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Evaluation of reinforcing capability of delta-9-tetrahydrocannabinol in rhesus monkeys

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Abstract

Harnessed rhesus monkeys, surgically prepared with indwelling jugular catheters, were given access by means of remotely controlled infusion pumps to unlimited quantities of delta-9-trans-tetrahydrocannabinol. Naive monkeys as well as monkeys which were automatically infused with THC for over 28 days did not self-administer THC. Monkeys which had a history of multiple drug self-administration also did not self-infuse THC.

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Authors and Affiliations

  1. Dept. of Physiology, Baylor College of Medicine, Houston, Texas

    Robert T. Harris

  2. Behavioral Pharmacology Dept., Texas Research Institute of Mental Sciences, Houston, Texas

    William Waters

  3. Dept. of Physiology, Baylor College of Medicine, Houston, Texas

    David McLendon

Authors
  1. Robert T. Harris
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  2. William Waters
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  3. David McLendon
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Additional information

Research supported by NIMH grant DA-00667.

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Harris, R.T., Waters, W. & McLendon, D. Evaluation of reinforcing capability of delta-9-tetrahydrocannabinol in rhesus monkeys. Psychopharmacologia 37, 23–29 (1974). https://doi.org/10.1007/BF00426679

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  • DOI: https://doi.org/10.1007/BF00426679

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