Abstract
LSD administration in rats elicited a diphasic reaction consisting of a brief excitable period (up to 8 min) followed by a prolonged catalepsy(8 min–1 h). While the cataleptic response was antagonized by a single injection of naloxone (given 30 min after LSD administration), pretreatment with naloxone shortened the excitable phase and potentiated the catalepsy.
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References
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Fertziger, A.P., Fischer, R. Interaction between narcotic antagonist (naloxone) and lysergic acid diethylamide (LSD) in the rat. Psychopharmacology 54, 313–314 (1977). https://doi.org/10.1007/BF00426582
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DOI: https://doi.org/10.1007/BF00426582