Abstract
The effect of naloxone on the latency of mice to enter a dark box was determined and the study of Jacob et al. (1974) on the effect of naloxone on hotplate behavior was replicated. Mice took significantly longer to enter a dark box after receiving 10 mg/kg of naloxone than did the saline controls. With the hot-plate technique, at all doses (0.1, 0.3, 1, 3, and 10 mg/kg) except the lowest (0.03 mg/kg), naloxonetreated mice jumped from the hot plate significantly sooner than did the saline controls. No effect of naloxone on paw-lick latency was found. All the data confirm the findings of Jacob et al. (1974). The hotplate results suggest that prolonged exposure to a noxious stimulus may be necessary to activate the endorphin system.
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References
Akil, H., Mayer, D. J., Liebeskind, J. C.: Antagonism of stimulation-produced analgesia by naloxone, a narcotic antagonist. Science 191, 961–962 (1976)
Cox, B. M., Opheim, E. E., Teschemacher, H., Goldstein, A.: A peptide-like substance from pituitary that acts like morphine. 2. Purification and properties. Life Sci. 16, 1777–1782 (1975)
Goldstein, A.: Opioid peptides (endorphins) in pituitary and brain. Science 193, 1081–1086 (1976)
Goldstein, A., Pryor, G. T., Otis, L. S., Larsen, F.: On the role of endogenous opioid peptides: Failure of naloxone to influence shock escape threshold in the rat. Life Sci. 18, 599–604 (1976)
Holtzman, S. G., Jewett, R. E.: Stimulation of behavior in the rat by cyclazocine: Effects of naloxone. J. Pharmacol. exp. Ther. 187, 380–390 (1973)
Hughes, J.: Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine. Brain Res 88, 295–308 (1975)
Jacob, J. J., Tremblay, E. C., Colombel, M. C.: Facilitation de réactions nociceptives par la naloxone chez la souris et chez le rat. Psychopharmacologia (Berl.) 37, 217–223 (1974)
Mason, J. W.: A review of the psychoendocrine research on the pituitary-adrenal cortical system. Psychosom. Med. 30, 576–607 (1968)
Pasternak, G. W., Goodman, R., Snyder, S. H.: An endogenous morphine-like factor in mammalian brain. Life Sci. 16, 1765–1769 (1975)
Siegel, S.: Nonparametric statistics for the behavioral sciences. New York: McGraw-Hill 1956
Stewart, D., Getto, C. J., Neldner, K., Reeve, E. B.: Substance P and analgesia. Nature (Lond.) 262, 784–785 (1976)
Terenius, L., Wahlstrom, A.: Inhibitor(s) of narcotic receptor binding in brain extracts and cerebrospinal fluid. Acta pharmacol. (Kbh.) 35 [Suppl.], 55 (1974)
Teschemacher, H., Opheim, K. E., Cox, B. M., Goldstein, A.: A peptide-like substance from the pituitary that acts like morphine. 1. Isolation. Life Sci. 16, 1771–1776 (1975)
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Grevert, P., Goldstein, A. Some effects of naloxone on behavior in the mouse. Psychopharmacology 53, 111–113 (1977). https://doi.org/10.1007/BF00426478
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DOI: https://doi.org/10.1007/BF00426478