Abstract
d-Amphetamine was injected into isolated and aggregated rats at a dose of 4 mg/kg. Treatment of individually caged rats led to no difference in striatal dopamine elimination compared to controls. Aggregation of animals, however, resulted in an increased striatal elimination of dopamine.
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References
Anton AH, Sayre DF (1962) A study of the factors affecting the aluminium oxide trihydroxyindole procedure for analysis of catecholamines. J Pharmacol Exp Ther 138:360–375
Anton AH, Sayre DF (1964) The distribution of dopamine and dopa in various animals and a method for their determination in diverse biological material. J Pharmacol Exp Ther 145:326–336
Besson MJ, Cheramy A, Feltz P, Glowinski J (1969) Release of newly synthesized dopamine from dopamine containing terminals in the striatum of the rat. Proc Natl Acad Sci 62:741
Carruba MO, Picotti GB, Zamotti F, Mantegazza P (1977) Mazindol and amphetamine as inhibitors of the uptake and release of 3H dopamine by rat striatal synaptosomes. Naunyn-Schmiedeberg's Arch Pharmacol 298:1–5
Chiueh CC, Moore KD (1975) d-Amphetamine-induced release of newly synthesized and stored dopamine from the caudate nucleus in vivo. J Pharmacol Exp Ther 192:642–653
Lewander T (1971) Effects of chronic amphetamine intoxication on the accumulation in rat brain of labelled catecholamine synthesized from circulating tyrosine 14C and dopa 3H. Naunyn-Schmiedeberg's Arch Pharmacol 271:211–233
Lokiec F, Jacquot, C, Cohen Y (1977) Effects of amphetamine on brain biogenic amines in isolated and aggregated rats. Eur J Pharmacol 44:391–395
Lokiec F, Rapin JR, Jacquot C, Cohen Y (1978) A comparison of the kinetics of d-and l-amphetamine in the brain of isolated and aggregated rats. Psychopharmacology 58:73–77
Raiteri M, Bertollini A, Angelini F, Levi G (1975) d-Amphetamine as a releaser or reuptake inhibitor of biogenic amines in synatosomes. Eur J Pharmacol 34:189–195
Raiteri M, Levi G (1978) Release mechanisms for catecholamines and serotonin in synaptosomes. Rev Neurosci 3:77–130
Vendsalu A (1960) Studies on adrenaline and noradrenaline in human plasma. Acta Physiol Scand 49:Suppl 173:10–123
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Lokiec, F., Cohen, Y. & Jacquot, C. Cageing density and dopamine striatal elimination after amphetamine in the rat. Psychopharmacology 73, 402–403 (1981). https://doi.org/10.1007/BF00426476
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DOI: https://doi.org/10.1007/BF00426476