Abstract
After stereotaxically injecting male mice of the inbred strains C57BL/6 and DBA/2 with two doses of methylscopolamine or with two doses of neostigmine into the left dorsal hippocampus, the frequencies of the exploratory acts rearing, leaning, and sniffing carried out in a novel environment were recorded. At the lower dose-level, the anticholinergic drug tended to augment exploration in strain DBA and to reduce it in strain C57BL; the two doses of anticholinesterase diminished the scores in both genotypes. From these data it is concluded that the hippocampus contains a cholinergic mechanism which regulates exploratory behaviour and which is genetically controlled.
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van Abeelen, J., Gilissen, L., Hanssen, T. et al. Effects of intrahippocampal injections with methylscopolamine and neostigmine upon exploratory behaviour in two inbred mouse strains. Psychopharmacologia 24, 470–475 (1972). https://doi.org/10.1007/BF00423437
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DOI: https://doi.org/10.1007/BF00423437