Summary
Adult male rats were progressively trained 5 days/week on a motor-driven treadmill. The training period lasted 12 weeks and consisted of 60 min/day of wind-sprints and endurance work. No significant difference in resting heart rates was observed between the control and exercise groups during week 1 (394±7 vs. 388±5). However, at week 12 the exercise group had a lower resting heart rate (359±6 vs. 331±4). Heart rates observed following saline, propranolol, atropine, and propranolol plus atropine injections were lower in the exercise group in all cases. The difference in heart rates between the control and exercise groups was 19 beats/min following propranolol plus atropine which was less than the 28 beats/min difference observed under control conditions. With atropine and then with propranolol the differences were 33 and 27 beats/min. These heart rate differences were observed without the presence of cardiac hypertrophy as assessed from ventricle weights.
Our data indicate that the bradycardia resulting from exercise training is due primarily to changes other than neural influences on the heart.
Similar content being viewed by others
References
Barnard, R. J., Duncan, H. W., Thorstensson, A. T.: Heart rate responses of young and old rats to various levels of exercise. J. appl. Physiol. 36, 472–474 (1974)
Bolter, C. P., Hughson, R. L., Critz, J. P.: Intrinsic rate and cholinergic sensitivity of isolated atria from trained and sedentary rats. Proc. Soc. exp. Biol. (N.Y.) 144, 364–367 (1973)
DeSchryver, C., Mertens-Strythagen, J.: Intensity of exercise and heart tissue catecholamine content. Pflügers Arch. 336, 345–354 (1972)
Dowell, R. T., Tipton, C. M.: Influence of training on heart rate responses of rats to isoproterenol and propranolol. Physiologist 13, 182 (1970)
Ekblom, B., Kilbom, A., Soltysiak, J.: Physical training, bradycardia and autonomic nervous system. Scand. J. clin. Lab. Invest. 32 251–256 (1973)
Frick, M. H., Elovainio, R. O., Somer, T.: The mechanism of bradycardia evoked by physical training. Cardiologia 51, 46–54 (1967)
Gollnick, P. D., Simmons, S. W.: Physical activity and liver cholesterol. Int. Z. angew. Physiol. 23, 322–330 (1967)
Herrlich, H. C., Raab, W., Gigee, W.: Influence of muscular training and of catecholamines oncardiac acetylcholine and cholinesterase. Arch. int. Pharmacodyn. 129, 201–215 (1960)
Kauf, E.: über die Einwirkung von Atropin und Adrenalin auf das Herz Sporttreibender. Wien. klin. Wschr. 39, 212–214 (1926)
Lin, Y., Horvath, S. M.: Autonomic nervous control of cardiac frequency in the exercise-trained rat. J. appl. Physiol. 33, 796–799 (1972)
Longo, V. G.: Behavioral and electroencephalographic effects of atropine and related compounds. Pharmacol. Rev. 18 965–996 (1966)
Ostman, I., Sjostrand, N. O., Swedin, G.: Cardiac noradrenalin turnover and urinary catecholamine excretion in trained and untrained rats during rest and exercise. Acta physiol. scand. 86, 299–308 (1972)
Raab, V., DePaula, E., Silva, P., Marchet, H., Kimura, E., Starcheska, J. K.: Cardiac adrenergic preponderance due to lack of physical exercise and its pathologic implications. Amer. J. Cardiol. 5, 300–321 (1960)
Sutton, J. R., Cole, A., Gunning, J., Hickie, J. B., Seldon, W. A.: Control of heart rate in healthy young men. Lancet 1967 II, 1398–1400
Tipton, C. M.: Training and bradycardia in rats. Amer. J. Physiol. 209, 1089–1094 (1965)
Tipton, C. M., Barnard, R. J., Tcheug, T.: Resting heart rate investigations with trained and nontrained hypophysectomized rats. J. appl. Physiol. 26, 585–588 (1969)
Tipton, C. M., Barnard, R. J., Tharp, G. D.: Cholinesterase activity in trained and nontrained rats. Int. Z. angew. Physiol. 23, 34–41 (1966)
Tipton, C. M., Taylor, B.: Influence of atropine on heart rates of rats. Amer. J. Physiol. 208, 480–484 (1965)
Author information
Authors and Affiliations
Additional information
Supported by a USPHS Career Development Award HL 00052-01
Rights and permissions
About this article
Cite this article
Barnard, R.J., Corre, K. & Cho, H. Effect of training on the resting heart rate of rats. Europ. J. Appl. Physiol. 35, 285–289 (1976). https://doi.org/10.1007/BF00423288
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00423288