Summary
Peripheral blood flow was measured during periods of good and poor metabolic control in juvenile diabetics with less than five years duration of the disease. Previously insulin treated patients, in whom the insulin was withdrawn for a few days, showed elevated blood flow in muscular, adipose and cutaneous tissue, whereas a group of newly diagnosed diabetics before treatment showed elevated blood flow in adipose and cutaneous tissue only. In good metabolic control the diabetics had normal values of both muscular, adipose and cutaneous tissue blood flow. In poorly controlled diabetics blood pressure, pulse rate and body temperature were elevated. These parameters are also normalized when the metabolism is brought under control. It is suggested, that the increased peripheral blood flow seen in diabetics in poor control is the effect of a generally increased turn-over of energy in combination with local factors, different from tissue to tissue.
Article PDF
Similar content being viewed by others
References
Abramson, D.I.: Circulation in the extremities, p. 408. New York: Academic Press 1967
Abramson, D.I., Fierst, S.M.: Resting peripheral blood flow in the hyperthyroid state. Arch. intern. Med. 69, 409–416 (1942)
Alexander, K., Teusen, R., Mitzkat, H.J.: Vergleichende Messungen der Extremitätendurchblutung bei Diabetikern und Stoffwechselgesunden. Klin. Wschr. 46, 234–238 (1968)
Benedict, F.G., Joslin, E.P.: A study of metabolism in severe diabetes. Washington: Carnegie Institute 1912
Benzinger, T.H., Taylor, G.W.: Temperature, its measurement and control in science and industry, ch. 10. (Ed. Hertzfeld, C.M.). New York: Reinhold Publishing Corporation 1963
Butterfield, W.J.H., Holling, H.E.: Peripheral glucose metabolism in fasting control subjects and diabetic patients. Clin. Sci. 18, 147–174 (1959)
Butterfield, W.J.H., Whichelow, M.J.: Peripheral glucose metabolism in control subjects and diabetic patients during glucose, glucose-insulin and insulin sensitivity tests. Diabetologia 1, 43–53 (1965)
Christensen, N.J.: Notes on the glucose oxidase method. Scand. J. clin. Lab. Invest. 19, 379–384 (1967)
Christensen, N.J.: A reversible vascular abnormality associated with diabetic ketosis. Clin. Sci. 39, 539–548 (1970)
Christensen, N.J.: Diabetic angiopathy and neuropathy. Acta med. scand. Suppl. 541 (1972)
Holten, C.: The respiratory metabolism in diabetics and the influence of insulin upon it. (Thesis) Copenhagen: Levin and Munksgaard Publishers 1925
Häggendal, E., Kerstell, J., Steen, B., Svanborg, A.: Blood flow and uptake of oxygen and substrates in forearm muscle and subcutaneous fat tissue in man. Acta med. scand. 183, 79–82 (1968)
Häggendal, E., Steen, B., Svanborg, A.: Blood flow in subcutaneous fat tissue in patients with diabetes mellitus. Acta med. seand. 187, 49–53 (1970)
Larsen, O.A., Lassen, N.A., Quaade, F.: Blood flow through human adipose tissue determined with radioactive xenon. Acta physiol. scand. 66, 337–345 (1966)
Laurell, S., Tibbling, G.: Colorimetric microdetermination of free fatty acids in plasma. Clin. chim. Acta 16, 57–62 (1967)
Levin, Nielsen, S., Bitsch, V., Larsen, O.A., Lassen, N. A., Quaade, F.: Blood flow through human adipose tissue during lipolysis. Scand. J. clin. Lab. Invest. 22, 124–130 (1968)
Quaade, F., Larsen, O.A., Lassen, N.A., Levin Nielsen, S.: Observations on the influence of glucose upon subcutaneous adipose tissue blood flow. Acta med. scand. Suppl. 476, 85–90 (1967)
Sejrsen, P.: Blood flow in cutaneous tissue in man studied by washout of radioactive xenon. Circulat. Res. 25, 215–229 (1969)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gundersen, H.J.G. Peripheral blood flow and metabolic control in juvenile diabetes. Diabetologia 10, 225–231 (1974). https://doi.org/10.1007/BF00423039
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00423039