Summary
Twenty-eight male subjects underwent a maximal exercise test on an ergometric bicycle, 13 untrained and 15 trained subjects.
At rest and after this maximal exercise, indicated by the increase of the serum lactate and pyruvate acids, venous blood samples were taken to study the release of muscular enzymes (SGOT, SGPT, LDH, α HBDH, CPK, CPK MB) and myoglobin in the next 24 h (3 min, 30 min, 8 h and 24 h after the end of this test).
The statistic analysis of the results shows significant increases in comparison with the values at rest, according to the enzymes and the groups of subjects, especially for CPK, SGOT, SGPT for which the results are homogeneous with a peak at the 3rd min and the 8th h in the three groups and for HBD and LDH in the groups of trained subjects.
However these values remain most often within the normal limits.
These results are compared with those of previous works on the same subjects.
Résumé
Vingt-huit sujets masculins ont pratiqué une épreuve d'effort maximale sur bicyclette ergométrique, 13 témoins et 15 sportifs.
Au repos et au décours de cet effort se traduisant par une augmentation notable des lactates et pyruvates seriques, des prélèvements de sang veineux ont été effectués afin d'analyser la libération des enzymes SGOT, SGPT, LDH, α HBDH, CPK, CPK MB et de la myoglobine.
L'analyse statistique des résultats met en évidence une élévation significative par rapport aux taux de repos, variables selon les enzymes et les groupes, notamment pour les CPK, SGOT, SGPT, pour lesquelles les résultats sont homogènes avec un pic à la 3è min et à la 8è h dans tous les groupes et pour les HBDH et LDH dans les groupes sportifs.
Toutefois ces valeurs restent le plus souvent dans les limites de la normale.
Ces résultats traduisant une libération des enzymes musculaires après effort maximal sont comparés à ceux de la littérature.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Bibliographie
Altland PD, Highman B (1961) Effects of exercise on serum enzyme values and tissues of rats. Am J Physiol 201: 393–395
Artigue RS, Hyman WA (1976) The effect of myoglobin on the oxygen concentration in skeletal muscle subjected to ischemia. Ann Biomed Eng 4: 128–137
Berson SA, Yalow RS (1978) General principles of radio immuno assay. Clin Chim Acta 22: 51–69
Bouget J (1979) IntérÊt de la myoglobinémie dans l'infarctus du myocarde. Thèse pour le doctorat en Médecine, Rennes
Broustet JP (1973) La réadaptation des coronariens. Sandoz Edn
Chahine RA, Kazantzis A, Luchi RJ, Raizner AE, Gyorrey F (1976) Effect of routine treadmill testing on the serum enzymes. Cardiology 61: 162–169
Demos MA, Gitin EL, Kagen LJ (1974) Exercise myoglobinemia and acute exertional rhabdomyolysis. Arch Intern Med 134: 669–673
Fowler WM Jr, Chowbury SR, Pearson GM, Gardner G, Bratton R (1962) Charges in serum enzyme levels after exercise in trained and untrained subjects. J Appl Physiol 17: 943–946
Garbus J, Highman B, Atland PD (1964) Serum enzymes and lacticodes hydrogenase isoenzymes after exercise and training in rats. Am J Physiol 207: 467–472
Hess JW, MacDonald RP, Frederick RJ (1964) Serum creatine phosphokinase activity in disorders of heart and skeletal muscle. Ann Intern Med 61: 1015
Hunter JB, Critz JB (1971) Effect of training on plasma enzyme levels in man. J Appl Physiol 31: 20–23
Kaman RL, Goheen B, Patton R, Raven P (1977) The effects of near maximum exercise on serum enzymes: the exercise profile versus the cardiac profile. Clin Chim Acta 81: 145–152
Ledwich JR (1973) Changes in serum creatine phosphokinase during submaximal exercise testing. Can Med Assoc J 109: 273–278
Levy G, Gautier JP (1974) Taux de certains enzymes après épreuve d'effort. Nouv Presse Med 3: 93
Nuttall FQ, Jones B (1968) Creatine kinase and glutamis oxaloacetic transaminase in serum: kinetics of change with exercise and effect of physical conditioning. J Lab Clin Med 71: 847–854
Petit M (1977) L'intérÊt des isoenzymes de la CPK en cardiologie. Thèse Poitiers 1977
Przyjemski CJ (1978) Creatine kinase isoenzymes in heart disease. Lancet 2: 1211
Ritter WS, Stone MJ, Willerson JT (1978) Reduction in exertional myoglobinemia following physical conditioning. Circulation 57–58: 8
Roberts R, Ambos HD, Carlson EM (1975) Improved quantification of myocardial infarction based on analysis of serum CPK isoenzymes. Am J Cardiol 35: 166A
Rosano TG, Sanders LA, Johnson ES, Kenny MA, Clayson KH, Strandjord PE (1977) Myoglobin concentrations and muscle enzyme activities in serum after myocardial infarction and cardiac arhythmia. Clin Chem 23: 868–870
Rose LI, Lowe SL, Carroll DR, Wolfson S, Cooper KH (1970) Serum lactate deshydrogenase isoenzyme changes after muscular exertion. J Appl Physiol 28: 279–281
Steele BW, Gobel FL, Nelson RR, Yasmineh WG (1978) Creatine kinase isoenzyme activity following cardiac catheterisation and exercise stress testing. Chest 73: 489–496
Stone RJ, Waterman MR, Harimoto D, Murray G, Willson N, Platt MR, Blonoquist G, Willerson IT (1977) Serum myoglobin level as diagnostic test in patients with acute myocardial infarction. Br Heart J 39: 375
Tzankoff SP, Norris AH (1979) Age-related differences in lactate distribution kinetics following maximal exercise. Eur J Appl Physiol 42: 35–40
Vejjajiva A, Teasdale GM (1965) Serum creatine kinase and physical exercise. Br Med J 1: 1653–1654
Wolfson S, Rose LL, Bousser JE, Parisi AF, Acosta AE, Cooper KH, Schechter E (1972) Serum enzyme levels during exercise in patients with coronary heart disease: effects of training. Am Heart J 84: 478
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Besson, C., Rochcongar, P., Beauverger, Y. et al. Etude des variations des taux seriques des enzymes musculaires et de la myoglobine après épreuve d'effort maximale et au cours des 24 heures suivantes. Europ. J. Appl. Physiol. 47, 47–56 (1981). https://doi.org/10.1007/BF00422482
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00422482