Abstract
When two animals were placed in a hole-board the number of headdips made by each rat was twice the number made when tested alone, but was the same for pairs of drugged (2 mg/kg chlorpromazine) and undrugged rats, and for pairs where only one rat was drugged. This contrasts with the reduction of headdipping produced by chlorpromazine in single animals. However, chlorpromazine still reduced general motor activity, regardless of whether the partner was drugged or not. The activity of the undrugged rats was affected by the partner's state and was lower when the partner was drugged.
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Boissier, J., Simon, P.: La Reaction d'exploration chez la souris. Therapie 17, 1225–1232 (1962)
Dorr, M., Steinberg, H., Tomkiewicz, M., Joyce, D., Porsolt, R., Summerfield, A.: Persistence of dose related behaviour in mice. Nature (Lond.) 231, 121–123 (1971)
File, S.: Effects of chlorpromazine on exploration and habituation in the rat. Brit. J. Pharmacol. 49, 303–310 (1973a)
File, S.: Potentiation of the effects of chlorpromazine on exploration and habituation in the rat by a prior experience of the drug. Psychopharmacologia (Berl.) 29, 357–363 (1973b)
File, S., Day, S.: Effects of time of day and food deprivation on exploratory activity in the rat. Anim. Behav. 20, 758–762 (1972)
Hughes, R.: Chlordiazepoxide modified exploration in rats. Psychopharmacologia (Berl.) 24, 462–469 (1972)
Kumar, R.: Effects of chlordiazepoxide and chlorpromazine on fear and exploratory behaviour in rats. Psychopharmacologia (Berl.) 19, 297–312 (1971)
Marriott, A., Spencer, P.: Effects of centrally acting drugs on exploratory behaviour in rats. Brit. J. Pharmacol. Chemother. 25, 432–441 (1965)
Maxwell, D.: Principles of animal experimentation in psycho-pharmacology. In: Psychopharmacology, Ed. C. Joyce. London: Tavistock Publications 1968
Nolan, N., Parkes, M.: The effects of Benzodiazepines on the behaviour of mice on a hole-board. Psychopharmacologia (Berl.) 29, 277–288 (1973)
Shillito, E.: The effects of chlorpromazine and thioridazine on the exploration of a Y-maze by rats. Brit. J. Pharmacol. Chemother. 30, 258–264 (1967)
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File, S.E., Pope, J.H. The action of chlorpromazine on exploration in pairs of rats. Psychopharmacologia 37, 249–254 (1974). https://doi.org/10.1007/BF00421538
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DOI: https://doi.org/10.1007/BF00421538