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Dose effects of smoked marihuana on human cognitive and motor functions

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Abstract

Graded doses of marihuana were administered to five adults in a longitudinal repeated-measurements design. Speed of response was the basic parameter measured across tests of increasing cognitive involvement. Marihuana produced significant dose-response effects of impaired performance in all test scores. However, single automatic motor abilities demonstrated greater sensitivity than tests of greater complexity. Evidence is presented for tolerance development.

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References

  • Abel, E. L.: Marihuana and memory: acquisition or retrieval. Science 173, 1038–1040 (1971)

    Google Scholar 

  • Bech, P., Rafaelsen, L., Rafaelsen, O. J.: Cannabis and alcohol: Effects on estimation of time and distance. Psychopharmacologia (Berl.) 32, 373–381 (1973)

    Google Scholar 

  • Borg, J.: Dose of smoked cannabis upon human cognitive and motor functions. Published doctoral dissertation, Yeshiva University, New York (1973)

    Google Scholar 

  • Caldwell, D. F., Myers, S. A., Domino, E. F., Merriam, P. E: Auditory and visual threshold effects of marihuana in man. Percept. Motor Skills 29, 755–759 (1969)

    Google Scholar 

  • Cappell, H., Kuchar, E., Webster, C. D.: Some correlates of marihuana self-administration in man: A study of titration of intake as a function of drug potency. Psychopharmacologia (Berl.) 29, 177–184 (1973)

    Google Scholar 

  • Cappell, H., Webster, C. D., Herring, B. S., Ginsberg, R.: Alcohol and marihuana; a comparison of effects on a temporally controlled operant in humans. J. Pharmacol. exp. Ther. 182, 195–203 (1972)

    Google Scholar 

  • Clark, L. D., Nakashima, E. N.: Experimental studies of marihuana. Amer. J. Psychiat. 125, 379–384 (1968)

    Google Scholar 

  • Clark, L. D., Hughes, R., Nakashima, E. N.: Behavioral effect of marihuana. Arch. gen. Psychiat. 23, 193–198 (1970)

    Google Scholar 

  • Darley, C. F., Tinklenberg, J. R., Hollister, L. E., Atkinson, R. C.: Marihuana and retrieval from short-term memory. Psychopharmacologia (Berl.) 29, 231–238 (1973a)

    Google Scholar 

  • Darley, C. F., Tinklenberg, J. R., Roth, W. T., Hollister, L. E., Atkinson, R. C.: Influence of marihuana on storage and retrieval processes in memory. Memory and Cognition 1, 196–200 (1973b)

    Google Scholar 

  • Dittrich, A., BÄttig, K., von Zeppelin, I.: Effects of (−)δ9-Trans-tetrahydrocannabinol (δ9-THC) on memory, attention and subjective state. Psychopharmacologia (Berl.) 33, 369–376 (1973)

    Google Scholar 

  • Domino, E. F., Rennick, P., Pearl, J. H.: Dose-effect relations of marihuana smoking on various physiological parameters in experienced male users. Clin. Pharmacol. Ther. 15, 514–520 (1974)

    Google Scholar 

  • Dornbush, R. L., Fink, M., Freedman, A. M.: Marihuana memory and perception. Amer. J. Psychiat. 128, 1265–1267 (1971)

    Google Scholar 

  • Galanter, M., Wyatt, R. J., Lemberger, L., Weingartner, H., Vaughan, T. B., Roth, W. T.: Effect on humans of δ9-tetrahydrocannabinol administered by smoking. Science 176, 934–936 (1972)

    Google Scholar 

  • Halpern, F.: Psychological aspects. Intellectual functioning. In: Mayor's committee on marihuana. The marihuana problem in the city of New York, pp. 81–106. Lancaster, Pa.: Jacques Cattell Press 1944

    Google Scholar 

  • Head, H.: Aphasia. Cambridge: University Press 1926

    Google Scholar 

  • Hollister, L. E.: Marihuana in man: three years later. Science 172, 21–29 (1971)

    Google Scholar 

  • Hollister, L. E., Gillespie, H. K.: Marihuana, ethanol and dextroamphetamine. Arch. gen. Psychiat. 23, 199–203 (1970)

    Google Scholar 

  • Hull, C. L.: Influence of tobacco smoking on mental and motor efficiency. Psych. Monographs No. 3, 33 (1924)

    Google Scholar 

  • Isbell, H., Gorodetzsky, C. W., Jasinski, D., Claussen, U., Spulak, F., Korte, F.: Effects of (−)δ9-trans-tetrahydrocannabinol in man. Psychopharmacologia (Berl.) 11, 184–188 (1967)

    Google Scholar 

  • Jones, R. T.: Tetrahydrocannabinol and the marihuana induced social “high”, or the effects of the mind on marihuana. In: Marihuana: chemistry, pharmacology, and patterns of social use. A. Singer, ed. Ann. N.Y. Acad. Sci. 191, 155–165 (1971)

  • Jones, R. T., Stone, G. C.: Psychological studies of marihuana and alcohol in man. Psychopharmacologia (Berl.) 18, 108–117 (1970)

    Google Scholar 

  • Karlin, L.: Reaction time as a function of foreperiod duration and variability. J. exp. Psychol. 58, 185–191 (1959)

    Google Scholar 

  • King, H. E.: Psychomotor aspects of mental diasease. An experimental study. Cambridge, Mass.: Harvard University Press 1954

    Google Scholar 

  • King, H. E.: Reaction time and speed of voluntary movement by normal and psychotic subjects. J. Psychol. 59, 219–227 (1965)

    Google Scholar 

  • Kiplinger, G. F., Manno, J. E., Rodda, B. E., Forney, R. B.: Dose response analysis of the effects of tetrahydrocannabinol in man. Clin. Pharmacol. Ther. 12, 650–657 (1971)

    Google Scholar 

  • Manno, J. E., Kiplinger, G. F., Haine, S. E., Bennett, I. F., Forney, R. B.: Comparative effects of smoking marihuana or placebo on human motor and mental performance. Clin. Pharmacol. Ther. 11, 808–815 (1970)

    Google Scholar 

  • Megles, F. T., Tinklenberg, J. R., Hollister, L. E., Gillespie, H. K.: Marihuana and temporal disintegration. Science 168, 118–120 (1970)

    Google Scholar 

  • Meyer, R. E., Pillar, R. C., Shapiro, L. M., Mirin, S. M.: Administration of marihuana to heavy and casual users. Amer. J. Psychiat. 128, 198–204 (1971)

    Google Scholar 

  • Pearl, J. H., Domino, E. F., Rennick, P.: Short term effects of marihuana smoking on cognitive behavior in experienced male users. Psychopharmacologia (Berl.) 31, 13–24 (1973)

    Google Scholar 

  • Rafaelsen, L., Christrup, H., Bech, P., Rafaelsen, O. J.: Effects of cannabis and alcohol on psychological tests. Nature (Lond.) 242, 117–118 (1973)

    Google Scholar 

  • Secretary, Department of Health, Education, and Welfare: A report to congress: Marihuana and health. U.S. Government Printing Office, Washington, D.C., 1971, 1972, 1974

    Google Scholar 

  • Tinklenberg, J. R., Kopell, B. C., Megles, F. T., Hollister, L. E.: Marihuana and alcohol. Time production and memory functions. Arch. gen. Psychiat. 27, 812–815 (1972)

    Google Scholar 

  • Tinklenberg, J. R., Megles, F. T., Hollister, L. E., Gillespie, H. K.: Marihuana and immediate memory. Nature (Lond.) 226, 1171–1172 (1970)

    Google Scholar 

  • Weil, A., Zinberg, N. E.: Acute effects of marihuana on speech. Nature (Lond.) 222, 434–437 (1969)

    Google Scholar 

  • Weil, A. T., Zinberg, N. E., Nelson, J. M.: Clinical and psychological effects of marihuana. Science 162, 1234–1242 (1968)

    Google Scholar 

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Authors and Affiliations

  1. Neuropsychopharmacology Research Unit, New York University Medical Center, New York

    Jacob Borg & Samuel Gershon

  2. Department of Psychiatry, New York University Medical Center, New York

    Murray Alpert

Authors
  1. Jacob Borg
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  2. Samuel Gershon
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  3. Murray Alpert
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Additional information

This research was supported by USPHS Grant MH-04669.

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Borg, J., Gershon, S. & Alpert, M. Dose effects of smoked marihuana on human cognitive and motor functions. Psychopharmacologia 42, 211–218 (1975). https://doi.org/10.1007/BF00421258

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  • DOI: https://doi.org/10.1007/BF00421258

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