Abstract
Cocaine injected pre-trial (10 mg/kg i.p.) improves performance in naive and high-performance (HP) and low-performance (LP) trained rats. When the effect of cocaine is removed, the number of conditioned responses decreases and equals that of drugless sessions. Cocaine favors only performance, not retention.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Castellano, C.: Lysergic acid diethylamide, amphetamine and chlorpromazine on water maze discrimination in mice. Psychopharmacologia (Berl.) 19, 16–26 (1971)
Castellano, C.: Cocaine, pemoline and amphetamine on learning and retention of a discrimination test in mice. Psychopharmacologia (Berl.) 36, 67–76 (1974)
Castellano, C., Sansone, M., Renzi, P., Annecker, L.: Central stimulant drugs on avoidance behavior in hamster. Pharmacol. Res. Com. 5, 287–293 (1973)
Ortiz, A., Montalban, P. L.: Efectos de la administratión aguda y crónica de la cocaína sobre la adquisición de reflejos condicionados en la rata. Rev. méd. Peru 3, 93–110 (1963)
Scheckel, C. L., Boff, E.: Behavioral effects of interacting imipramine and other drugs with d-amphetamine, cocaine and tetrabenazine. Psychopharmacologia (Berl.) 5, 198–208 (1964)
van Rossum, J. M., van der Shoot, J. B., Hurkmans, J. A. Th.: Mechanism of action of cocaine and amphetamine in the brain. Experientia (Basel) 18, 229–231 (1962)
van Rossum, J. M., van der Shoot, J. B., Hurkmans, J. A. Th.: Mechanism of action of psychomotor stimulant drugs. Int. J. Neuropharmacol. 3, 227–239 (1964)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Torrelio, M., Izquierdo, J.A. Pre-trial cocaine and performance in rat. Psychopharmacologia 45, 283–285 (1976). https://doi.org/10.1007/BF00421141
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00421141