Summary
This study was designed to review the clinical experience of cementation in the treatment of giant cell tumor of bone and to clarify its biologic basis. Eleven patients treated by this technique had results rated excellent. No recurrences of the tumor were found. Serious complications, including infection, late fracture, or secondary osteoarthrosis, did not occur. The possibility of immediate fixation and stabilization of large defects is the most valuable point of this method. Local recurrence seems to be easily detectable by magnetic resonance imaging. A cell line of mononuclear cells from giant cell tumor of bone was examined for its response to hyperthermic exposure. Hyperthermic treatment was carried out at temperature of 60° for 10 min and in other conditions. The numbers of cells surviving after heat treatment were counted, and flow cytometry was used to analyze the positive rate of surface antigens of the cells and the pattern of DNA distribution at the different temperatures. The heat treatment caused a fair number of the cells to fall into S-phase, and the tetraploid value was very low. The higher the temperature and the longer the time, the fewer cells survived and the less the expression of the monocytic phenotype. No cells survived after heating at 60° for 10 min. Cementation seemed to have a hyperthermic effect to the cells of giant cell tumor of bone.
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References
Caballes RL (1981) The mechanism of metastasis in the so-called benign giant cell tumor of bone. Hum Pathol 12:762–767
Dahlin DC, Cupps RE, Johnson EW (1970) Giant-cell tumor. A study of 195 cases. Cancer 25:1061–1070
Drexler HG, Sagawa K, Menon M, Minowada J (1985) “Panmyeloid” reagent: the monoclonal antibody MCS-2 in the routine immunodiagnostic service of leukemia phenotyping. Jpn J Cancer Res 76:235–239
Enneking WF (1987) Modification of the system for functional evaluation of surgical management of musculoskeletal tumors. In: Enneking WF (ed) Limb salvage in musculoskeletal oncology. Churchill Livingstone, NewYork, pp 626–639
Goldenberg RR, Campbell CJ, Bonfiglio M (1970) Giant-cell tumor of bone. An alaysis of two hundred and eighteen cases. J Bone Joint Surg [Am] 52:619–664
Hara A, Yokoyama MM (1989) The monoclonal antimonocyte antibody JML H-14. Fourth International Workshop and Conference on Human Leucocyte Differentiation Antigens, Vienna
Komiya S, Inoue A, Nakashima M, Ueno A, Fujikawa K, Ikuta H (1986) Prognostic factors in giant cell tumor of bone. A modified histological grading system useful as a guide to prognosis. Arch Orthop Trauma Surg 105:67–72
Komiya S, Sasaguri Y, Inoue A, Nakashima M, Yamamoto S, Yanagida I, Morimatsu M (1990) Characterization of cells cultured from giant-cell tumors of bone. Phenotypic relationship to the monocyte-macrophage and osteoclast. Clin Orthop 258:304–309
Malawer MM, Dunham W (1991) Cryosurgery and acrylic cementation as surgical adjuncts in the treatment of aggressive (benign) bone tumors. Analysis of 25 patients below the age of 21. Clin Orthop 262:42–57
Malawer MM, Marks MR, McChesney D, Piasio M, Gunther SF, Schmookler BM (1988) The effect of cryosurgery and polymethylmethacrylate in dogs with experimental bone defects comparable to tumor defects. Clin Orthop 226:229–310
Marcove RC, Weis LD, Vaghaiwalla MR, Pearson R (1972) Cryosurgery in the treatment of giant cell tumors of bone. A report of 52 censecutive cases. Clin Orthop 134:275–289
Mnaymneh WA, Dudley HR, Mnaymneh L (1964) Giant-cell tumor of bone. An analysis and follow-up study of forty-one cases observed at the massachusetts General Hospital between 1925 and 1960. J Bone Joint Surg [Am] 46:63–75
Persson BM, Wouters HW (1976) Curettage and acrylic fixation cementation in surgery of giant cell tumor of bone. Clin Orthop 120:125–133
Persson BM, Rydholm A, Berlin O, Gunterberg B (1987) Curettage and acrylic cementation in surgical treatment of giant cell tumors. In: Enneking WF (ed) Limb salvage in musculoskeletal oncology. Churchill Livingstone, NewYork, p 476
Rock MG, Pritchard DJ, Unni KK (1984) Metastases from histologically benign giant-cell tumor of bone. J Bone Joint Surg [Am] 66:269–273
Sanerkin NG (1980) Malignancy, aggressiveness, and recurrence in giant cell tumor of bone. Cancer 46:1641–1649
Sung HW, Kuo DP, Chai YB, Lui CC, Li SM (1982) Giant-cell tumor of bone. Analysis of two hundred and eight cases in Chinese patients. J Bone Joint Surg [Am] 64:7557–761
Taminiau AHM, Wouters HW (1987) Treatment of giant cell tumors by curettage and cementation. In: Enneking WE (ed) Limb salvage in musculoskeletal oncology. Churchill Livingstone, NewYork, p 477
Wilkins RM, Okada Y, Sim FH, Chao EYS, Gorgki J (1987) Methylmethacrylate replacement of subchondral bone: a biomechanical, biochemical, and morphologic analysis. In: Enneking WF (ed) Limb salvage in musculoskeletal oncology. Churchill Livingstone, NewYork, pp 479–485
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Komiya, S., Inoue, A. Cementation in the treatment of giant cell tumor of bone. Arch Orthop Trauma Surg 112, 51–55 (1993). https://doi.org/10.1007/BF00420253
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DOI: https://doi.org/10.1007/BF00420253