Abstract
Susceptibility to the induction of murine autoimmune orchitis was found to be associated with the locus controlling Bordetella pertussis-induced sensitivity to the vasoactive amine, histamine. Only those inbred and H-2 congenic strains of mice possessing both the H-2 d haplotype and the locus for susceptibility to B. pertussis-induced sensitivity to histamine developed autoimmune orchitis. In addition, segregation analysis of backcross generation mice also demonstrated a high degree of correlation between susceptibility both to disease and to histamine sensitization, which was indicative of additional multigene control. Pertussigen-histamine sensitization factor (P-HSF) was only effective in eliciting disease when it was administered on the same day, or within a period up to 6 days following sensitization with mouse testicular homogenate-emulsified in complete Freund's adjuvant. P-HSF induced sensitivity to histamine was not found to be associated with an increase in the vascular permeability of target tissue. Thus, B. pertussis-induced sensitivity to histamine appears to play a more crucial role during the sensitization phase of autoimmune orchitis induction, rather than at the inflammatory or effector phase of the disease.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bernard, C. C. A., Mitchell, G. F., Leydon, J., and Bargerbos, A.: Experimental autoimmune orchitis in T-cell-deficient mice. Int. Arch. Allergy Appl. Immunol. 56: 256–263, 1978
Bohme, D.: Response of reticuloendothelial system to experimental allergic orchitis in a genetically susceptible and resistant mouse genotype. Proc. Soc. Exp. Biol. Med. 118: 374–376, 1965
Bradbury, M.: The Concept of a Blood-Brain Barrier, John Wiley Sons Ltd., Sussex, England, 1979
David, C. S.: H-2 regulation of autoimmune and infectious diseases. In T. Sasazuki and T. Tada (eds.): Immunogenetics. Its Application to Clinical Medicine, pp. 63–74, Academic Press Inc. Ltd., London, England, 1984
Dym, M. and Fawcett, D. W.: The blood-testis barrier in the rat and the physiological compartmentation of the seminiferous epithelium. Biol. Reprod. 3: 308, 1970
Gershon, R. K., Askenase, P. W., and Gershon, M. D.: Requirement for vasoactive amines for production of delayed-type hypersensitivity skin reactions. J. Exp. Med. 142: 732–747, 1975
Gilula, N. B., Fawcett, D. W., and Aoki, A.: The sertoli cell occluding junctions and gap junctions in mature and developing mammalian testis. Dev. Biol. 50: 142–168, 1976
Hargis, B. J., Malkiel, S., and Berkelhammer, J.: Immunologically induced aspermatogenesis in the white mouse. J. Immunol. 101: 374–376, 1968
Hunter, W. M. and Greenwood, F. C.: Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature 194: 495–496, 1962
Kohno, S., Munoz, J. A., Williams, T. M., Teuscher, C., Bernard, C. C. A., and Tung, K. S. K.: Immunopathology of murine experimental allergic orchitis. J. Immunol. 130: 2675–2682, 1983
Lando, Z. and Ben-Nun, A.: Experimental autoimmune encephalomyelitis mediated by T-cell line. II. Specific requirements and the role of pertussis vaccine for the in vitro activation of the cells and induction of disease. Clin. Immunol. Immunopathol. 30: 290–303, 1984
Levine, S. and Sowinski, R.: Experimental allergic encephalomyelitis in inbred and outbred mice. J. Immunol. 110: 139–143, 1973
Linthicum, D. S.: Development of acute autoimmune encephalomyelitis in mice: Factors regulating the effector phase of the disease. Immunobiology 162: 211–220, 1982
Linthicum, D. S. and Frelinger, J. A.: Acute autoimmune encephalomyelitis in mice. II. Susceptibility is controlled by the combination of H-2 and histamine sensitization genes. J. Exp. Med. 156: 31–40, 1982
Linthicum, D. S., Munoz, J. J., and Blaskett, S.: Acute experimental autoirnmune encephalomyelitis in mice. I. Adjuvant action of Bordetella pertussis is due to vasoactive amine sensitization and increased vascular permeability of the central nervous system. Cell. Immunol. 73: 299–310, 1982
Munoz, J. J. and Arai, H.: Studies on crystalline pertussigen. In J. B. Robbins, J. C. Hill, and J. C. Sadoff (eds.): Seminars in Infectious Diseases, Volume IV: Bacterial Vaccines, pp. 395–400, Thieme-Stratton Inc., New York, 1982
Munoz, J. J. and Bergman, R. K.: Bordetella pertussis: Immunological and other biological activities. Immunol. Ser. 4: 1–235, 1977
Munoz, J. J., Bernard, C. C. A., and Mackay, I. R.: Elicitation of experimental allergic encephalomyelitis in mice with the aid of pertussigen. Cell. Immunol. 83: 92–100, 1984
Ovary, Z., Vris, T. W., De Szalay, C., Vaz, N. M., and Iritani, C. A.: Independent segregation of the H-2 locus and the locus for responsiveness to histamine-sensitizing factor. Proc. Natl. Acad. Sci. U.S.A. 70: 2500–2501, 1973
Porkorná, Z., Vojtíšková, M., Rychlíková, M., and Chutná, J.: An isologous model of experimental autoimmune aspermatogenesis in the mouse. Folia Biol.(Praha) 9: 203–209, 1963
Sato, K., Hirokawa, K., and Hatakeyama, S.: Experimental allergic orchitis in mice. Histopathologic and immunological studies. Virchows Arch. (Pathol. Anat.) 392: 147–158, 1981
Sewell, W. A., Munoz, J. J., and Vadas, M. A.: Enhancement of the intensity, duration and passive transfer of delayed-type hypersensitivity by pertussigen in mice. J. Exp. Med. 157: 2087–2096, 1983
Sewell, W. A., Munoz, J. J., Scollay, R., and Vadas, M. A.: Studies on the mechanism of the enhancement of delayed-type hypersensitivity by pertussigen. J. Immunol. 133: 1716–1722, 1984
Siegel, J. N., Schwartz, A., Askenase, P. W., and Gershon, R. K.: T-cell suppression and contra-suppression induced by histamine H2 and H1 receptor agonists, respectively. Proc. Natl. Acad. Sci. U.S.A. 79: 5052–5056, 1982
Teuscher, C., Smith, S. M., Goldberg, E. H., Shearer, G. M., and Tung, K. S. K.: Experimental allergic orchitis in mice. I. Genetic control of susceptibility and resistance to induction of autoimmune orchitis. Immunogenetics 22: 323–333, 1985a
Teuscher, C., Potter, M., and Tung, K. S. K.: Differential susceptibility to experimental autoimmune orchitis in BALB/c substrains. Curr. Top. Microbiol. Immunol., in press, 1985b
Wardlaw, A. C.: Inheritance of responsiveness to pertussis HSF in mice. Int. Arch. Allergy Appl. Immunol. 38: 573–589, 1970
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Teuscher, C. Experimental allergic orchitis in mice. Immunogenetics 22, 417–425 (1985). https://doi.org/10.1007/BF00418088
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00418088