Summary
In allergic reactions induced by drugs we detected elevated platelet activating factor (PAF) bioactivity in blood and we isolated a substance with activity and chemical characteristics similar to AGEPC (semisynthetic PAF, beef-heart derived PAF). The levels of the circulating substance were about ten times higher than the ones detected in normal subjects.
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Lazanas, M., Demopoulos, C.A., Tournis, S. et al. PAF of biological fluids in disease: I.V. Levels in blood in allergic reactions induced by drugs. Arch Dermatol Res 280, 124–126 (1988). https://doi.org/10.1007/BF00417717
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DOI: https://doi.org/10.1007/BF00417717