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Epidermis and lymphocyte interactions during a tuberculin skin reaction

I. Increased ETAF/II-1 like activity, expression of tissue antigens and mixed skin lymphocyte reactivity

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Summary

Forty-one persons were tested for tuberculin skin reactivity. Epidermal cells (ECs) were isolated from the tuberculin reaction and from a contra lateral, non injected skin area. We found a significant increase of epidermal thymocyte activating factor (ETAF) in epidermis overlying a positive tuberculin reaction together with an increase of OKT6 and class II (HLA-DR) positive cells. Allogeneic lymphocytes proliferated significantly more when mixed with ECs from a positive tuberculin skin test. Injection of tuberculin per se or a negative reaction did not induce similar changes. The described model seems useful for functional studies of ECs and lymphocytes in patients with contact dermatitis.

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Authors and Affiliations

  1. Department of Dermatology, Marselisborg Hospital, University of Aarhus, DK-8000, Aarhus C, Denmark

    C. G. Larsen, T. Ternowitz, F. G. Larsen & K. Thestrup-Pedersen

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  1. C. G. Larsen
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  2. T. Ternowitz
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  3. F. G. Larsen
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  4. K. Thestrup-Pedersen
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Larsen, C.G., Ternowitz, T., Larsen, F.G. et al. Epidermis and lymphocyte interactions during a tuberculin skin reaction. Arch Dermatol Res 280, 83–88 (1988). https://doi.org/10.1007/BF00417709

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  • DOI: https://doi.org/10.1007/BF00417709

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