Abstract
The influence of various inhibitors of hyphal growth, sporulation and biosynthesis of aflatoxin B1 in Aspergillus parasiticus NRRL 2999 was studied. 6-Thioguanine, dl-ethionine, fluoroacetic acid and phenylboric acid, inhibitors of maturation of fungal conidiophores and of conidiogenesis, were added at various concentrations to malt extract agar. Lower concentrations of 6-thioguanine and dl-ethionine did not inhibit the growth of hyphae and the sporulation. Phenylboric acid reduced conidiogenesis more than hyphal growth. The yields of aflatoxin B1 were significantly reduced. Additions of fluoroacetic acid did not greatly affect the growth of hyphae but totally inhibited the production of conidia and concurrently significantly reduced the formation of aflatoxin B1. An interrelation between conidiogenesis and onset of secondary metabolism in A. parasiticus is evident.
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References
Behal FJ (1959) Biochemical studies of spore formation in Aspergillus niger. Arch Biochem Biophys 84:151–156
Behal FJ, Eakin RE (1959) Inhibition of mold development by purine and pyrimidine analogs. Arch Biochem Biophys 82:439–447
Bird BA, Remaley AT, Campbell IM (1981) Brevianamides A and B are formed only after conidiation has begun in solid cultures of Penicillium brevicompactum. Appl Environ Microbiol 42:521–525
Bu'Lock JD (1961) Intermediary metabolism and antibiotic synthesis. Adv Appl Microbiol 3:293–342
Detroy RW, Freer SN (1973) Methionine regulation of aflatoxin biosynthesis by Aspergillus parasiticus. Dev Ind Microbiol 15:124–132
Maximos A (1967) Über die Aflatoxinbildung bei Aspergillus flavus. Zbl Bakt I Abt, Ref 206:532
Maximos A, Haccius B (1961) Hemmung der Konidienbildung bei Aspergillus oryzae durch Phenylborsäure. Naturwissenschaften 48:677–678
Ramaut JL, Vanderhoven C, Remacle J (1970) Étude de la production d'aflatoxine B1 en fonction des étapes du développement morphologique d'Aspergillus flavus Link. Rev Ferm Ind Aliment 25:184–189
Reiß J (1971) Wachstum von Aspergillus flavus und Aflatoxinbildung in geschnittenem und verpacktem Weizenvollkornbrot. Z Lebensmittelunters Forsch 145:155–158
Reiß J (1975) Semiquantitative estimation of aflatoxins on thin-layer chromatograms with a gray scale. Anal Biochem 55:643–645
Reiß J (1982) Comparison of the ability of three Aspergillus strains to form aflatoxins on bakery products and on nutrient agar. Mycopathologia 77:99–102
Sekiguchi J, Gaucher GM (1977) Conidiogenesis and secondary metabolism in Penicillium urticae. Appl Environ Microbiol 33:147–158
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Reiß, J. Development of Aspergillus parasiticus and formation of aflatoxin B1 under the influence of conidiogenesis affecting compounds. Arch. Microbiol. 133, 236–238 (1982). https://doi.org/10.1007/BF00415008
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DOI: https://doi.org/10.1007/BF00415008