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The disciform response: An historical perspective

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Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Abstract

This paper is a survey of the literature in an attempt to provide the basis for our current understanding of the disciform process. Particular emphasis is placed on its pathogenesis and the role of subretinal neovascularization. No two lesions appear exactly alike because of the many stages and combinations possible. Gass (1967) has delineated the broad spectrum with the many different clinical manifestations of this disease process. Verhoeff and Grossman (1937) provided the histopathologic basis for our understanding of the disciform process. The histologic correlation of the clinical “predisciform” state would seem to offer the most promising information for understanding the pathogenesis of the disciform process (Frank et al. 1973; Green and Key 1977; Kornweig 1967; Sarks 1973 and 1976; Small et al. 1976; Zauberman 1970).

It is hoped that this literature review has sufficiently emphasized the inherent deficiencies of strictly clinical studies and the need for an appropriate experimental animal model (Ryan 1979).

Zusammenfassung

Die vorliegende Arbeit gibt einen Überblick über die bisherige Literatur, um die Basis unseres gegenwärtigen Wissens um die „disciformen Prozesse” darzustellen.

Besonderes Gewicht wird auf die Pathogenese und die Rolle von subretinalen Gefäßproliferationen gelegt. Aufgrund möglicher Kombinationen und Stadien sieht jede Läsion unterschiedlich aus (Gass 1977). Das breite Spektrum wird mit den verschiedenartigen klinischen Manifestationen dieses Krankheitsprozesses beschrieben.

Verhoeff und Grossman (1937) beschrieben erstmals die histo-pathologischen Grundlagen für unser gegenwärtiges Verständnis von disciformen Prozessen. Die Gegenüberstellung von histologischem und klinischem Befund des „prädisciformen Stadiums verspricht am meisten zum Verständnis der Pathogenese von disciformen Prozessen beizutragen (Frank et al. 1973; Green and Key 1977; Kornweig 1967; Sarks 1973, 1976; Small et al. 1976; Zauberman 1970).

Mit vorliegender Literaturübersicht wird versucht, die unumgänglichen Lücken in den ausschließlich klinischen Studien darzustellen und die Notwendigkeit für ein adequates tierexperimentelles Modell aufzuzeigen (Ryan 1980).

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Authors and Affiliations

  1. Johns Hopkins Medical Institutions, Wilmer Ophthalmological Institute, USA

    Stephen J. Ryan, Rainer N. Mittl & A. Edward Maumenee

  2. Department of Ophthalmology, University of Southern California and the Estelle Doheny Eye Foundation, USA

    Stephen J. Ryan, Rainer N. Mittl & A. Edward Maumenee

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  1. Stephen J. Ryan
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  2. Rainer N. Mittl
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  3. A. Edward Maumenee
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Additional information

Dr. Ryan was a recipient of the Louis B. Mayer Scholar Award from Research to Prevent Blindness, Inc., New York, New York, during the period of this work

This work was funded in part by two grant awards from the National Institutes of Health, National Eye Institute, EY-00944 and EY-01545

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Ryan, S.J., Mittl, R.N. & Maumenee, A.E. The disciform response: An historical perspective. Albrecht von Graefes Arch. Klin. Ophthalmol. 215, 1–20 (1980). https://doi.org/10.1007/BF00413392

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