Summary
A single acute injection and 14 daily injections of 100 mg/kg of cocaine did not alter the brain content of noradrenaline or the adrenal gland content of adrenaline and noradrenaline in rats. The urinary adrenaline and noradrenaline was greatly increased, however, during 14 days of cocaine administration. On the 14th day of treatment the sum of adrenaline and noradrenaline in the urine was five times the normal level. After withdrawal there was a slow return, especially of the urinary noradrenaline which was not quite normal 17 days after withdrawal.
The findings are discussed in relation to the known dependence-producing properties of cocaine and compared with those of morphine.
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Gunne, L.M., Jonsson, J. Effects of cocaine administration on brain, adrenal and urinary adrenaline and noradrenaline in rats. Psychopharmacologia 6, 125–129 (1964). https://doi.org/10.1007/BF00413225
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DOI: https://doi.org/10.1007/BF00413225