Summary
A case of ochronosis-like pigmentation of the hands is described. The following criteria were fulfilled: (1) presence of blue to black spots confined to the hands; (2) pitch-black macroscopic appearance of the biopsy specimen; (3) abundance of granular material in the whole connective structures on microscopic examination of an unstained specimen just mounted on a slide; (4) numerous pigmented granules in the elastic and the collagen fibers; (5) no family history, abnormal coloration of the urine, taking of drugs, or rheumatism; (6) onset in a manual worker exposed to benzenic substances.
This seems to be a new entity, probably a variant of exogenous ochronosis produced by professional contacts with some agents and perhaps a professional benzenic ochronosis.
Zusammenfassung
Es wird der Fall einer ochronoseartigen Pigmentation der Hand beschrieben. Es handelt sich dabei
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1.
um schwarze Herde nur an den Händen,
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2.
bereits makroskopisch erkennbare schwarze Verfärbung des histologischen Schnittes,
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3.
reichlich granuläres Material im Bindegewebe bei der mikroskopischen Untersuchung der ungefärbten Präparate,
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4.
zahlreiche pigmentierte Granula in den clastischen und Kollagenfasern,
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5.
keine anamnestischen Hinweise in der Familienanamnese, weder Urinverfärbung, Arzneimittelmißbrauch oder Rheumatismus,
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6.
Beginn der Veränderungen nach Kontakt mit hydrochinonhaltigen Arbeitsstoffen.
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Dupré, A., Bonafé, JL., Viraben, R. et al. Idiopathic pigmentation of the hands. Professional exogenous ochronosis? A new entity?. Arch. Dermatol. Res. 266, 1–9 (1979). https://doi.org/10.1007/BF00412856
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DOI: https://doi.org/10.1007/BF00412856