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Die transmurale Druckdifferenz der Widerstandsgefäße als Parameter der Widerstandsregulation in der Niere

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Summary

The effect of intrarenal tissue pressure, which accompanies osmotic diuresis, ureteral occlusion, applied pelvic pressure or elevated renal venous pressure, on intrarenal resistance to flow was investigated in anesthetized dogs.

Resistance of muscle-type precapillary vessels (pre- and postglomerular arterioles included) decreased with increasing tissue pressure. The decrease of flow resistance was directly related to decrease of transmural pressure difference in this vascular segment. The model behaviour which best describes the observed results is that of vascular smooth muscle reaction to changes in tangential wall tension as opposed to the behaviour of a purely elastic system. Mean transmural pressure difference of the precapillary vascular segment, at which smooth muscle contraction commences, was found to be 30–35 mm Hg.

Intrarenal venous resistance increased when intrarenal tissue pressure was elevated. However, at normal BP ranges, this increase in venous resistance does not exceed precapillary dilation, so that only constancy or a net increase in total renal blood flow occured. Blood flow oscillations after sudden decrease of intrarenal pressure could be invariably abolished by papaverine.

The results suggest that the observed intrarenal resistance changes are caused by vascular smooth muscle reactions to altered wall tension and that the increase in total renal blood flow during osmotic diuresis is not a specific effect of osmotically active substances.

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Authors and Affiliations

  1. Aus dem Physiologischen Institut der Universität Göttingen, Germany

    Klaus Thurau & Günter Henne

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  1. Klaus Thurau
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  2. Günter Henne
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Mit 7 Textabbildungen

Mit Unterstützung der Deutschen Forschungsgemeinschaft und des U. S. Department of the Army, European Research Office.

Stipendiat der Deutschen Forschungsgemeinschaft.

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Thurau, K., Henne, G. Die transmurale Druckdifferenz der Widerstandsgefäße als Parameter der Widerstandsregulation in der Niere. Pflügers Archiv 279, 156–177 (1964). https://doi.org/10.1007/BF00412776

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