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Diuresis induced by water infusion into the carotid loop and its inhibition by small hemorrhage

The competition of volume- and osmocontrol

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Zusammenfassung

An fünf wachen, trainierten Hunden wurde die Wirkung des lokalen osmotischen Reizes einer Wasserinfusion von 3 ml/min über 30 min in eine Carotisschlinge allein und kombiniert mit einer gleichzeitigen Entnahme von 8% des geschätzten Blutvolumens auf die Ausscheidungsfunktion der Niere untersucht. Folgende Ergebnisse wurden beobachtet:

Die intracarotidiale Wasserinfusion verursachte stets eine Diurese. Wurden während der ersten 10 min der Infusion 150 ml Blut entnommen, so blieb die Diurese aus, obwohl diese Blutentnahme keinen Einfluß auf Blutdruck und Herzfrequenz hatte.

In der Mehrzahl der Fälle führte die Retransfusion des entnommenen Blutes prompt zu einer Diurese. Bei allen Eingriffen war die Änderung der Urinsekretion fast ausschließlich bedingt durch eine Änderung der Freiwasserclearance. Ausscheidung der osmotisch wirksamen Stoffe blieb unverändert.

Es wird geschlossen, daß bei einem Wettstreit der osmoregulatorischen und volumenregulatorischen Systeme die ersteren überspielt werden, wenn die Erhaltung eines adäquaten Volumens gefährdet ist.

Summary

In five unanesthetized trained dogs the effect on urine flow of the osmotic stimulus of a slow intracarotid water infusion alone and combined with a mild hemorrhage of 8% of the estimated blood volume was investigated. The blood loss was too small to cause any change in blood pressure or heart rate.

In contrast to the effect of intracarotid infusion of 3 ml water/min over a 30 min period no diuresis occurred when this infusion was combined with a slow hemorrhage of 150 ml applied during the first 10 min of the infusion period.

In the majority of cases restoration of blood volume by retransfusion of the hemorrhaged blood was promptly followed by water diuresis.

In all maneuvers the diuresis was entirely due to a change in free water clearance. The excretion of osmotically active material was unchanged.

It is concluded that during a competition of the control systems of osmotic pressure and fluid volume the former is acutely overruled if the homeostasis of fluid volume is jeopardized.

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Authors and Affiliations

  1. W. G. Kerckhoff-Institut der Max Planck-Gesellschaft, Bad Nauheim

    Joachim O. Arndt

  2. School of Medicine, Department of Physiology and Biophysics, University of Washington, Seattle, Washington

    Joachim O. Arndt

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  1. Joachim O. Arndt
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With 3 Figures in the Text

This research was supported under the sposnorship of the Deutsche Forschungsgemeinschaft and Grant No. AF EOAR 62-75 U.S. Airforce, Brussels Office.

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Arndt, J.O. Diuresis induced by water infusion into the carotid loop and its inhibition by small hemorrhage. Pflügers Arch. 282, 313–322 (1965). https://doi.org/10.1007/BF00412506

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