Summary
The intraocular pressure of rabbits under urethan anaesthesia was found to be 20.8±2.4 mm Hg. 0.3 mg/kg body weight propranolol given intravenously lowered intraocular pressure to 18.8±1.3 mm Hg. The total facility of outflow from control eyes examined at constant pressures of perfusion was 0.309 ±0.09 μl/mm Hg/min, which was reduced to 0.237±0.08 μl/mm Hg/min by propranolol given systemically. The formation of aqueous humor in the control eyes was 2.16±0.78 μl/min, which was diminished to 1.15±0.64 μl/min by propranolol. The differences are statistically significant. The decrease in facility of outflow is smaller than the decrease in formation of aqueous humour, which accounts for the lower intraocular pressure. On the basis of the various and gently differing data in the literature it is assumed that propranolol may have some other mode of action in addition to its β-adrenolytic effect on receptors.
Zusammenfassung
Der intraoculare Druck der mit Urethan anaesthesierten Kaninchen betrug 20,8 mm Hg. I.v. verabreichtes Propranolol (Inderal, 0,3 mg/kg Körpergewicht) verringerte diesen Druck auf 18,8±1,3 mm Hg. Die totale Leichtigkeit des Kammerwasserabflusses an den Kontrollaugen betrug 0,309±0,090 μl/mm Hg/min, während sich nach Verabreichung von Propranolol dieser Wert auf 0,237 ±0,083 μl/mm Hg/min veränderte. Die Kammerwasserproduktion in den Kontrollaugen betrug 2,16±0,78 μl/min. Nach Verabreichung von Propranolol ging sie auf 1,15±0,64 μl/min zurück. Die Differenzen erwiesen sich als statistisch signifikant. Die Abnahme der Abflußleichtigkeit erscheint den Daten nach geringer als die Abnahme der Kammerwasserproduktion. Dadurch erklärt sich die Verringerung des intraocularen Druckes. Aufgrund des Vergleiches der verschiedenen und von einander abweichenden Literaturangaben vermuten die Verfasser, daß das Propranolol außer der tonusverringernden Wirkung auf die β-adrenergen Receptoren auch noch einen anderen Wirkungsmechanismus entfalten kann.
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Takáts, I., Szilvássy, I. & Kerek, A. Intraocularer Druck und Kammerwasserzirkulations-Untersuchungen an Kaninchenaugen nach intravenöser Verabreichung von Propranolol (Inderal®). Albrecht v. Graefes Arch. klin. exp. Ophthal. 185, 331–342 (1972). https://doi.org/10.1007/BF00410765
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DOI: https://doi.org/10.1007/BF00410765