Summary
The concurrent application of disulfiram (710 mg/kg diet; or 200 mg/kg diet) effects a strong enhancement of the toxicity and an acceleration of the formation of esophageal tumors by N-methyl-N-nitrosobenzylamine (10 mg/l drinking water) in female SIV 50 rats. Besides that squamous cell papilloma in the trachea and extended squamous cell metaplasia in the bronchus system with potentially but not safely precancerous nature were seen.
Zusammenfassung
Die gleichzeitige Applikation von Disulfiram (710 mg/kg Diät; bzw. 200 mg/kg Diät) bewirkt eine starke Erhöhung der Toxizität und eine Beschleunigung der Bildung von Oesophagustumoren durch N-Methyl-N-nitrosobenzylamin (10 mg/l Trinkwasser) bei weiblichen SIV 50 Ratten. Darüber hinaus entstehen Plattenepithelpapillome in der Trachea und ausgedehnte Plattenepithelmetaplasien im Bronchialsystem als potentiell aber nicht sicher präkanzeröse Veränderungen.
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Abbreviations
- DSF:
-
Disulfiram
- MNBA:
-
N-Methyl-N-nitrosobenzylamin
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Mit Unterstützung der Deutschen Forschungsgemeinschaft
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Schweinsberg, F., Bürkle, V. Wirkung von Disulfiram auf die Toxizität und Carcinogenität von N-Methyl-N-nitrosobenzylamin bei Ratten. J Cancer Res Clin Oncol 102, 43–47 (1981). https://doi.org/10.1007/BF00410533
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DOI: https://doi.org/10.1007/BF00410533