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Reduction of cardiac hypertrophy in TGR(mREN2)27 by angiotensin II receptor blockade

  • Part II: Cardiac Hypertrophy and Failure
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Abstract

TGR(mREN2)27 is a transgenic rat harboring the murine Ren-2 gene and exhibit fulminant hypertension and marked heart hypertrophy. In order to study the role of angiotensin II in the increase of cardiac mass, these animals were treated with anti-hypertensive and non-antihypertensive doses of the angiotensin II receptor AT1 antagonist Telmisartan for 9 weeks. All doses led to significant reductions of heart hypertrophy detected by the evaluation of the diameter of cardiac muscle bundles. We conclude from this study that cardiac hypertrophy in TGR(mREN2)27 is characterized by an increased volume of cardiomyocytes and an unchanged amount of fibrous tissue and that angiotensin II plays an important role in the mechanisms leading to this phenotype.

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Authors and Affiliations

  1. Max-Delbrück-Center for Molecular Medicine (MDC), Berlin-Buck

    Manfred Böhm, Andrea Lippoldt, Detlev Ganten & Michael Bader

  2. A Pharma Research, Dr. Karl Thomae GmbH, Biberach, Germany

    Wolfgang Wienen

Authors
  1. Manfred Böhm
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  2. Andrea Lippoldt
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  3. Wolfgang Wienen
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  4. Detlev Ganten
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  5. Michael Bader
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Böhm, M., Lippoldt, A., Wienen, W. et al. Reduction of cardiac hypertrophy in TGR(mREN2)27 by angiotensin II receptor blockade. Mol Cell Biochem 163, 217–221 (1996). https://doi.org/10.1007/BF00408661

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  • DOI: https://doi.org/10.1007/BF00408661

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