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Age changes of the human optic nerve head

A neurohistologic study

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Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Summary

Eleven human optic nerves from subjects in different decades ranging from the fifth to the ninth were investigated with the silver carbonate method to establish the pattern and frequency of age changes within the optic nerve head and their relationship with the glaucomatous excavation. It has been found that despite the occurrence of age degeneration at the same level of the cribriform lamina, there are definite anatomical differences as compared with glaucoma changes, especially regarding the distribution of axonal damage.

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References

  • Agduhr, E.: Einige Beiträge zur Ag.-Technik der Stückimpregnierung der Nerven. Anat. Anz. 69, 363–376 (1930)

    Google Scholar 

  • Anderson, D.R., Braverman, S.: Reevaluation of the optic disc vasculature. Amer. J. Ophth. 82 (2), 165–174 (1976)

    Google Scholar 

  • Cajal, S.R.: Degeneration and regeneration of the nervous system. Vol. II. p. 583–596, New York: Hafner, 1959

    Google Scholar 

  • Goder, G.: Die Veränderungen der Kapillarisation des Optikus und ihre pathogenetische Bedeutung. Angiologica, 3, 59–75 (1966)

    PubMed  Google Scholar 

  • Hollwich, F.: Senile Exkavation, In: Der Augenarzt, Vol. V. p. 755, Leipzig: Thieme, 1963

    Google Scholar 

  • Jabonero, V.: Eine neue Technik zur Färbung peripherer nervöser Elemente. Z. mikr. anat. Forsch. 59, 562–582 (1953)

    PubMed  Google Scholar 

  • Levy, N.S.: Functional implication of axoplasmic transport. Invest. Ophth. 13 (9), 639–640 (1974a)

    Google Scholar 

  • Levy, N.S.: The effects of elevated intraocular pressure on slow axonal protein flow. Invest. Ophth. 13 (9), 691–695 (1974b)

    Google Scholar 

  • Minckler, D.S., Tso, M.O.M.: A light microscopic, autoradiographic study of axoplasmic transport in the normal rhesus optic nerve head. Amer. J. Ophth. 82, 1–15 (1976a)

    Google Scholar 

  • Minckler, D.S., McLean, I.W., Tso, M.O.M.: Distribution of axonal and glial elements in the rhesus optic nerve head studied by electron microscopy. Amer. J. Ophth. 82, 179 179–187 (1976b)

    Google Scholar 

  • Sachsenweger, R.: Altern und Auge. Ein Hdb. der Gerontologie und Geriatrie des menschlichen Sehorgans. pp. 263–271, Leipzig: Thieme 1971

    Google Scholar 

  • Vrabec, Fr.: Spherical swelling of retinal axons in the aged. Brit. J. Ophth. 49, 113–119 (1965a)

    PubMed  Google Scholar 

  • Vrabec, Fr.: On the development and senile changes of the innervation of the trabecular meshwork in man. Structure of the Eye, II. Symposium. pp. 215–222, Stuttgart: Schattauer 1965b

    Google Scholar 

  • Vrabec, Fr.: The temporal raphé of the human retina. Amer. J. Ophth. 62, 926–938 (1966)

    Google Scholar 

  • Vrabec, Fr.: Age changes of the inner surface of the trabecular meshwork shown by the replica technique. Invest. Ophthalm. 13 (12), 950–953 (1974)

    Google Scholar 

  • Vrabec, Fr.: Glaucomatous cupping of the human optic disk. A. v. Graef. Arch. klin. exp. Ophthal. 198, 223–234 (1976)

    Google Scholar 

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Authors and Affiliations

  1. Eye Clinic of the Medical Faculty of Hygiene, Prague 10

    František Vrabec DrSc

  2. Ophthalmological Laboratory of the Institute of Experimental Medicine, Czechoslovakian Academy of Sciences, Prague 2

    František Vrabec DrSc

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  1. František Vrabec DrSc
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Vrabec, F. Age changes of the human optic nerve head. Albrecht von Graefes Arch. Klin. Ophthalmol. 202, 231–236 (1977). https://doi.org/10.1007/BF00407873

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  • DOI: https://doi.org/10.1007/BF00407873

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