Summary
Monkeys trained to perform in a delayed matching test under five delay conditions were given chlorpromazine hydrochloride (0.05, 0.1, 0.2 and 0.4 mg/kg) and pentobarbital sodium (1.0, 10.0 and 20.0 mg/kg) before test sessions. Both drugs decreased response rate proportionally as dose increased. Chlorpromazine initially depressed accuracy, but showed no specific effects as delay interval increased. Pentobarbital had little effect upon accuracy, although impairment on the simultaneous conditions was seen at the highest dose. It is concluded that neither drug produced specific effects upon short-term memory.
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References
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This work was supported by a USPHS grant MH 01225 and an Interdepartmental Institute for Training in the Neurologic and Behavioral Sciences grant 5T1 MH 6418.
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Glick, S.D., Goldfarb, T.L., Robustelli, F. et al. Impairment of delayed matching in monkeys by chlorpromazine and pentobarbital. Psychopharmacologia 15, 125–133 (1969). https://doi.org/10.1007/BF00407045
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DOI: https://doi.org/10.1007/BF00407045