Skip to main content
Log in

Further observations on the process of haemophagocytosis in the human outflow system

  • Published:
Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Aims and scope Submit manuscript

Summary

The outflow system was studied in seven human traumatised eyes in which there was a hyphaema (injury-enucleation periods 7 h to 35 days). Extracellular lysis of red cells was present, but lysed red cells were not found in the outer part of the meshwork. Exogenous macrophages and endogenous endothelial cells contained red cells and their breakdown products and evidence was obtained to indicate intracellular haemolysis as the cells passed through the meshwork. Penetration of the lining endothelium of Schlemm's canal by red cells and macrophages was a rare observation and this was attributed to the presence of a co-existing hypotonia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Adachi, H.: Pathological study in experimental Heinz body anaemia: intracellular changes of phagocytosed red cells in macrophages of the spleen and liver. Acta Path. Jap. 27, 657–675 (1977)

    Google Scholar 

  • Bill, A.: The effect of ocular hypertension caused by red cells on the rate of formation of aqueous humour. Invest. Ophthal. 7, 162–168 (1968)

    Google Scholar 

  • Campbell, D.G., Simmons, R.J., Grant, W.M.: Ghost cells as a cause of glaucoma. Amer. J. Ophthal. 81, 441–450 (1976)

    Google Scholar 

  • Fenton, R.H., Zimmerman, L.E.: Haemolytic glaucoma: an unusual cause of acute open angle secondary glaucoma. Arch. Ophthal. 70, 236–239 (1963)

    Google Scholar 

  • Grierson, I., Lee, W.R.: Erythrocyte phagocytosis in the human trabecular meshwork. Brit. J. Ophthal. 57, 400–415 (1973)

    Google Scholar 

  • Grierson, I., Lee, W.R.: The fine structure of the trabecular meshwork at graded levels of intraocular pressure. (1) Pressure effects within the near physiological range. Exp. Eye Res. 20, 505–521 (1975a)

    Google Scholar 

  • Grierson, I., Lee, W.R.: The fine structure of the trabecular meshwork at graded levels of intraocular pressure. (2) Pressures outside the physiological range. Exp. Eye Res. 20, 523–530 (1975b)

    Google Scholar 

  • Grierson, I., Lee, W.R.: Pressure-induced changes in the ultrastructure of the endothelium lining Schlemm's canal. Amer. J. Ophthal. 80, 863–884 (1975c)

    Google Scholar 

  • Hunter, W.S.: Haemolytic glaucoma. Tr. Amer. Acad. Ophthal. & Otolaryngol. 73, 95–98 (1969)

    Google Scholar 

  • Inomata, H., Bill, A., Smelser, G.K.: Aqueous humour pathways through the trabecular meshwork and into Schlemm's canal in the cynomolgus monkey (Macaca irus). Amer. J. Ophthal. 73, 760–789 (1972)

    Google Scholar 

  • Lee, W.R.: The study of the passage of particles through the endothelium of the outflow apparatus of the monkey eye by scanning and transmission electron microscopy. Trans. Ophthal. Soc. U.K. 91, 687–705 (1971)

    Google Scholar 

  • Lee, W.R., Grierson, I.: Relationships between intraocular pressure and the morphology of the outflow apparatus. Trans. Ophthal. Soc. U.K. 94, 430–449 (1974)

    Google Scholar 

  • Melsom, H., Kearny, G., Gruca, S., Seljelid, R.: Evidence for a cytolytic factor released by macrophages. J. Exp. Med. 140, 1085–1096 (1974)

    Google Scholar 

  • Rohen, J.W., van der Zypen, E.: The phagocytic activity of the trabecular meshwork endothelium. A. von Graefes Arch. klin. exp. Ophthal. 175, 143–160 (1968)

    Google Scholar 

  • Shabo, A.L., Maxwell, D.S.: Observations on the fate of blood in the anterior chamber. Amer. J. Ophthal. 73, 25–36 (1973)

    Google Scholar 

  • Tavassoli, M.: Intravascular phagocytosis in the rabbit bone marrow: a possible fate of normal senescent red cells. Brit. J. Haematol. 36, 323–326 (1977)

    Google Scholar 

  • Unanue, E.R.: Secretory function of mononuclear macrophages. Amer. J. Path. 83, 398–417 (1976)

    Google Scholar 

  • Yamashita, T., Rosen, D.: Electron microscopic study of the trabecular meshwork in clinical and experimental glaucoma with anterior chamber haemorrhage. Amer. J. Ophthal. 60, 427–434 (1965)

    Google Scholar 

  • Zeligs, J.D.: Ultrastructure of the degradation of erythrocytes by thyroid epithelial cells in vivo. Amer. J. Path. 89, 85–104 (1977)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Grierson, I., Lee, W.R. Further observations on the process of haemophagocytosis in the human outflow system. Albrecht von Graefes Arch. Klin. Ophthalmol. 208, 49–64 (1978). https://doi.org/10.1007/BF00406981

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00406981

Keywords

Navigation