Summary
The corticonigral projections from area 6 in the raccoon were investigated using the autoradiographic tracing method. Injections of tritiated proline and leucine were made into either medial or lateral area 6 subdivisions. Uniformly distributed silver grains were observed overlying the ipsilateral substantia nigra pars compacta (SNc) while more restricted foci of label indicative of fiber labeling were present in the substantia nigra pars reticulata (SNr). Autoradiographic label was also present in the substantia nigra pars lateralis (SNl), the retrorubral area and the ventral tegmental area of Tsai. The existence of corticonigral projections from area 6 may serve to modulate SNc activity as a whole and provide an important substrate for the cerebral control of movement.
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Abbreviations
- cp:
-
cerebral peduncle
- IP:
-
interpeduncular nucleus
- PG:
-
pontine gray
- R:
-
red nucleus
- RR:
-
retrorubral area
- SNc:
-
substantia nigra, pars compacta
- SNl:
-
substantia nigra, pars lateralis
- SNr:
-
substantia nigra, pars reticularis
- VTA:
-
ventral tegmental area
References
Afifi AK, Bahuth NB, Kaelber WW, Mikhael E, Nasser S (1974) The cortico-nigral fibre tract. An experimental Fink-Heimer study in cats. J Anat 118: 469–476
Alexander GE, DeLong MR, Strick PL (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 9: 357–381
Beckstead RM (1979) An autoradiographic examination of corticocortical and subcortical projections of the medio-dorsal projection (prefrontal) cortex in the rat. J Comp Neurol 184: 43–62
Berman AL, Jones EG (1982) The thalamus and basal telencephalon of the cat: a cytoarchitectonic atlas with stereotaxic coordinates. University of Wisconsin Press, Madison, Wisc.
Bunney BS, Aghajanian GK (1976) The precise localization of nigral afferents in the rat as determined by retrograde tracing technique. Brain Res 117: 423–435
Cowan WM, Gottlieb DI, Hendrickson AE, Price JL, Woolsey TA (1972) The autoradiographic demonstration of axonal connections in the central nervous system. Brain Res 37: 21–51
Gerfen CR, Staines WA, Arbuthnott GW, Fibiger HC (1982) Crossed connections of the substantia nigra in the rat. J Comp Neurol 207: 283–303
Goldberg G (1985) Supplementary motor area structure and function: review and hypothesis. Behav and Brain Sci 8: 567–616
Grofova I (1965) Frontal cortical projections to the midbrain tegmentum in the cat. Folia Morphol (Prague) 3: 305–315
Hassler K, Muhs-Clement K (1964) Architektonischer Aufbau des sensomotorischen und parietalen Cortex der Katze. J Hirnforsch 6: 377–420
Jameson HD, Arumugasamy N, Hardin WB (1968) The supplementary motor area in the raccoon. Brain Res 11: 628–637
Kornhuber J, Kim J-S, Kornhuber ME, Kornhuber HH (1984) The corticonigral projection: reduced glutamate content in the substantia nigra following frontal cortex ablation in the rat. Brain Res 322: 124–126
Künzle H (1978) An autoradiographic analysis of the efferent connections from premotor and adjacent prefrontal regions (areas 6 and 9) in Macaca fascicularis. Brain Beh Evol 15: 185–234
Mehler WR (1981) The basal ganglia-circa 1982: a review and commentary. Appl Neurophysiol 44: 261–290
Neafsey EF, Hull CD, Buchwald NA (1978) Preparation for movement in the cat. I. Unit activity in the cerebral cortex. EEG Clin Neurophysiol 44: 706–713
Nitsch C, Mews K, Wagner A, Hassler R (1984) Effects of frontal motor cortex ablation on the ultrastructure of cat substantia nigra. Acta Anat (Basel) 119: 193–202
Penney JB, Young AB (1983) Speculations on the functional anatomy of basal ganglia disorders. Annu Rev Neurosci 6: 73–94
Parent A (1986) Comparative neurobiology of the basal ganglia. Wiley, New York
Poirer LJ, Giguere M, Marchand R (1983) Comparative morphology of the substantia nigra and ventral tegmental area in the monkey, cat and rat. Brain Res Bull 11: 371–397
Rinvik E (1966) The cortico-nigral projection in the cat. Brain Res 126: 241–254
Rinvik E, Walberg F (1969) Is there a cortico-nigral tract? A comment based on experimental electron microscopic observations in the cat. Brain Res 14: 742–744
Sakai ST (1982) The thalamic connectivity of the primary motor cortex (MI) in the raccoon. J Comp Neurol 204: 238–252
Schell GR, Strick PL (1984) The origin of thalamic inputs to the arcuate premotor and supplementary motor areas. J Neurosci 4: 539–560
Stelmach GE, Worringham CJ, Strand EA (1987) The programming and execution of movement sequences in Parkinson's disease. Intern J Neurosci 36: 55–65
Stern Y, Mayeux R, Rosen J, Ilson J (1983) Perceptual motor dysfunction in Parkinson's disease: a deficit in sequential and predictive voluntary movement. J Neurol Neurosurg Psychiatr 46: 145–151
Tanaka D Jr, Sakai ST (1985) Corticostriate projections from area 6 in the raccoon. Exp Brain Res 58: 338–345
Usunoff KG, Romansky KV, Malinov GB, Ivanov DP, Blagov ZA, Galabov GP (1982) Electron microscopic evidence for the existence of a corticonigral tract in the cat. J Hirnforsch 23: 23–29
Vicario DS, Martin JH, Ghez C (1983) Specialized subregions in the cat motor cortex: a single unit analysis in the behaving animal. Exp Brain Res 51: 351–367
Wise SP (1985) The primate premotor cortex: fifty years after Fulton. Behav Brain Res 18: 79–88
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Sakai, S.T. Corticonigral projections from area 6 in the raccoon. Exp Brain Res 73, 498–504 (1988). https://doi.org/10.1007/BF00406607
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DOI: https://doi.org/10.1007/BF00406607