Summary
Levels of cadmium (CdB) and lead (PbB) were determined in the blood of 579 60–65 year-old residents of Cologne and two small cities near Cologne. CdB-levels in cigarette smokers are on the average 3–4 times higher than in non-smokers (geometric means: non-smokers, 0.44 μg/1; ≤ 10 cigaretrettes/d, 1.16 μg/l; > 10 cigarettes/d, 1.85 μg/1). The results indicate that, with regard to the internal dose, cadmium exposure via smoking may contribute even more than does exposure via food. PbB-levels (geometric mean: 8.49 μg/100 ml; range: 2.9–30.3 μg/100 ml) are in the acceptable range as defined by the CEC reference values. Male smokers have on the average slightly higher PbB-levels than male non-smokers. In women PbB-levels are on the average lower than in men.
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References
Friberg L, Piscator M, Nordberg GF, Kjellström T (1974) Cadmium in the environment, 2nd ed. CRC Press, Cleveland
Ulander A, Axelson O (1974) Measurement of blood-cadmium levels. Lancet 1:682
Zielhuis RL, Struik EJ, Herber RFM, Sallé HJA, Verberk MM, Posma FD, Jager JH (1977) Smoking habits and levels of lead and cadmium in blood in urban women. Int Arch Occup Environ Health 39:53–58
Wysowski DK, Landrigan PJ, Ferguson SW, Fontaine RE, Tsongas TA, Porter B (1978) Cadmium exposure in a community near a smelter. Am J Epidemiol 107:27–35
Buchet JP, Roels H, Hubermont G, Lauwerys R (1978) Placental transfer of lead, cadmium, and carbon monoxide in women. Environ Res 15:494–503
Stoeppler M, Brandt K (1979) Rapid determination of cadmium in whole blood and urine with electrothermal AAS. Proc. Internat. Conference “Management and Control of Heavy Metals in the Environment”. CEP Consultants Ltd. Edingburgh, pp 183–186
Pleban PA, Pearson KH (1979) Determination of cadmium in whole blood and urine by Zeeman atomic absorption spectroscopy. Clin Chim Acta 99:267–277
Kowal NE, Johnson DE, Kraemer DF, Pahren HR (1979) Normal levels of cadmium in diet, urine, blood and tissues of inhabitants of the United States. J Toxicol Environ Health 5:995–1014
Schaller KH (1981) Referat auf dem Fachgespräch “Cadmiuminduzierte Nierenfunktionsstörungen beim Menschen (Pathobiologie, Früherkennung, Epidemiologie, klinischprognostische Bewertung)” im Bundesgesundheitsamt, Berlin-W, am 21.10.1981. Manuskript
Elinder CG, Kjellström T, Linnman L, Pershagen G (1978) Urinary excretion of cadmium and zinc among persons from Sweden. Environ Res 15:473–484
Syversen TLM, Stray TK, Ofstad J (1976) Cadmium and zinc in human liver and kidney. Scand J Clin Lab Invest 36:251–256
Østergaard K (1977) The concentration of cadmium in renal tissue from smokers and non-smokers. Acta Med Scand 202:193–195
Østergaard K (1978) Renal cadmium concentration in relation to smoking habits and blood pressure. Acta Med Scand 203:379–383
Ellis KJ, Vartsky D, Zanzi J, Cohn SH (1979) Cadmium: in vivo measurement in smokers and nonsmokers. Science, NY 205:323–325
Elinder CG, Kjellström T, Friberg L, Lind B, Linnman L (1976) Cadmium in kidney cortex, liver, and pancreas from Swedish autopsies. Arch Environ Health 31:292–302
Roels H, Hubermont G, Buchet JP, Lauwerys R (1978) Placental transfer of lead, mercury, cadmium, and carbon-monoxide in women. Environ Res 16:236–247
Piscator M (1978) Exposure to cadmium. In: DiFerrante E (ed) Trace metals: exposure and health effects. Pergamon Press, Oxford, pp 35–41
World Health Organization (1977) Environmental Health Criteria 3—Lead. Geneva
Brockhaus A, Freier I, Ewers U, Baginski B, Krämer U, Dolgner R (1980) Epidemiologische Untersuchungen zur ökologischen Bleibelastung von männlichen Großstadt-bewohnern in Nordwestdeutschland. Int Arch Occup Environ Health 46:59–70
Grandjean P, Olsen NB, Hollnagel H (1981) Influence of smoking and alcohol consumption on blood lead levels. Int Arch Occup Environ Health 48:391–397
Tepper LB, Levin LS (1975) A survey of air and population lead levels in selected American communities. In: Griffin TB, Knelson JH (eds) Lead. Environmental quality and safety, Vol 11. Thieme, Stuttgart, pp 152–196
Lehnert G, Schaller KH, Kühner A, Szadkowski D (1967) Auswirkungen des Zigarettenrauchens auf den Blutbleispiegel. Int Arch Gewerbepath Gewerbehyg 25:358–363
McLaughlin M, Stopps GJ (1973) Smoking and lead. Arch Environ Health 26:131–136
Tola S, Nordman CH (1977) Smoking and blood lead concentrations in lead-exposed workers and an unexposed population. Environ Res 13:250–255
Ministerium für Arbeit, Gesundheit und Soziales NW (1983) Luftreinhalteplan Rheinschiene-Süd (Köln) 1982–1986. (in preparation)
Stoeppler M, Brandt K, Reins TC (1978) Contributions to automated trace analysis, Part II. Rapid method for the automated determination of lead in whole blood by electrothermal atomic absorption spectrometry. Analyst 103:714–722
Draper N, Smith H (1966) Applied regression analysis. Wiley & Sons, New York London Sydney
Commission of the European Communities (1977) Council Directive of 29. March 1977 on biological screening of the population for lead (77/312/EEC; OJ of the EC No L 105; 28. April, 1977)
Bergmann H, Hall G, Schaller KH (1980) Blutbleiuntersuchungen in Bayern im Rahmen einer EG-Studie. Bayer. Ärzteblatt, Heft 5/1980: 464–473
National Academy of Sciences/National Research Council (1972) Lead-airborne lead in perspective. Washington, DC
Mahaffey KR, Annest JL, Roberts J, Murphy RS (1982) National estimates of blood lead levels: United States, 1976–1980. N Engl J Med 307:573–579
Takenaka S, Oldiges H, König H, Hochrainer D, Oberdörster G (1982) Carcinogenicity of cadmium aerosols in Wistar rats. J Natl Cancer Inst (in press)
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Supported by a grant of the Ministerium für Arbeit, Gesundheit und Soziales des Landes Nordrhein-Westfalen
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Brockhaus, A., Freier, I., Ewers, U. et al. Levels of cadmium and lead in blood in relation to smoking, sex, occupation, and other factors in an adult population of the FRG. Int. Arch Occup Environ Heath 52, 167–175 (1983). https://doi.org/10.1007/BF00405420
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DOI: https://doi.org/10.1007/BF00405420