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Tolerance to the behavioral effects of scopolamine in rats

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Summary

Rats injected with scopolamine after daily training sessions on a fixed-interval schedule of reinforcement develop performances similar to those of uninjected controls rats. When all the rats are given the drug before the session, those originally trained with scopolamine after the session differ from the controls by showing as much tolerance to the drug as do rats trained from the start with scopolamine before the session.

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References

  • Boren, J. J., and A. P. Navarro: The action of atropine benactyzine, and scopolamine upon fixed-interval and fixed-ratio behavior. J. exp. Anal. Behav. 2, 107–115 (1959).

    PubMed  Google Scholar 

  • Charney, N. H., and G. S. Reynolds: Development of behavioral compensation to the effects of scopolamine during fixed-interval reinforcement. J. exp. Anal. Behav. 8, 183–186 (1965).

    Google Scholar 

  • Goodman, L. S., and A. Gilman: The pharmacological basis of therapeutics. (3rd. ed.) New York: Macmillan Comp. 1965.

    Google Scholar 

  • Herrnstein, R. J.: Effects of scopolamine on a multiple schedule. J. exp. Anal. Behav. 1, 351–358 (1958).

    Google Scholar 

  • Overton, D. A.: State-dependent or “dissociated” learning produced with pentobarbital. J. comp. physiol. Psychol. 57, 3–12 (1964).

    PubMed  Google Scholar 

  • Richelle, M.: A note on behavior tolerance to meprobamate. J. exp. Anal. Behav. 8, 45–46 (1965).

    Google Scholar 

  • Schuster, C. R., and J. Zimmermann: Timing behavior during prolonged treatment with dl-amphetamine. J. exp. Anal. Behav. 4, 327–330 (1961).

    PubMed  Google Scholar 

  • Waller, M. B.: Effects of chronically administered chlarpromazine in multiple-schedule performance. J. exp. Anal. Behav. 4, 351–359 (1961).

    PubMed  Google Scholar 

  • Whitehouse, J. M.: Effects of atropine on discrimination learning in the rat. J. comp. physiol. Psychol. 57, 13–15 (1964).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Psychology, University of California, San Diego, P.O. Box 109, 92037, La Jolla, California

    Nicholas H. Charney

Authors
  1. Nicholas H. Charney
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  2. G. S. Reynolds
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Additional information

Research supported by grants GB-316 and GB-2541 from the National Science Foundation and by grant MH-10397 from USPHS to the University of Chicago.

Charney was an NIMH predoctoral trainee

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Charney, N.H., Reynolds, G.S. Tolerance to the behavioral effects of scopolamine in rats. Psychopharmacologia 11, 379–387 (1967). https://doi.org/10.1007/BF00405021

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  • DOI: https://doi.org/10.1007/BF00405021

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