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Untersuchungen über mögliche Zusammenhänge zwischen Metabolitenausscheidung und Krankheitsverlauf depressiver Zustände unter Imipramin-Medikation

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Summary

The excretion of the known metabolites of Imipramine is described for 9 depressive cases. The amounts of the single metabolites excreted daily show considerable variations. It was attempted, using the case histories, to determine wether a parallel exists between the course of the disease and the metabolic excretion pattern. A definite correlation could not be found. However, there are indications that a relationship of this type may exist. Such a relationship would be complex and different for each phase of the treatment. It appears that Metabolite IV is of special importance for the antidepressive activity of Imipramine.

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  1. Heil- und Pflegeanstalt Münsterlingen, Kanton Thurgau, Schweiz

    R. Kuhn

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  1. R. Kuhn
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Tofranil®

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Kuhn, R. Untersuchungen über mögliche Zusammenhänge zwischen Metabolitenausscheidung und Krankheitsverlauf depressiver Zustände unter Imipramin-Medikation. Psychopharmacologia 8, 201–222 (1965). https://doi.org/10.1007/BF00405018

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  • DOI: https://doi.org/10.1007/BF00405018

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