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A research report on the anti-fatigue effects of magnesium pemoline

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Summary

The effects of magnesium pemoline were compared to those of caffeine and methylphenidate on the performance of a nonmotivated task which required continuous attention over a two hour testing period. The drug treatment consisted of: 25 or 50 mg magnesium pemoline, 100 or 200 mg caffeine, 15 mg methylphenidate or a placebo. Ten unhospitalized volunteers were each tested six times, once on each treatment. The significant increase in errors which occured under placebo conditions did not occur with 50 mg magnesium pemoline, or 200 mg caffeine or 15 mg methylphenidate. These results support the contention of others that magnesium pemoline acts as a nonspecific CNS stimulant.

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Authors and Affiliations

  1. Division of Psychiatry, Boston University School of Medicine Boston University Medical Center, USA

    Maressa Hecht Orzack, Constance L. Taylor & Conan Kornetsky

Authors
  1. Maressa Hecht Orzack
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  2. Constance L. Taylor
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  3. Conan Kornetsky
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Additional information

Part support by Grant from Abbott Laboratories and by USPHS, NIMH Grant MH 12568.

NIH Career Award Program 5-K3-GM-1759.

This work was performed at the Medfield Foundation, Medfield State Hospital, Medfield, Mass., under the medical supervision of Dr. Nizamettin Oktem and Dr. Harry Freeman, Director.

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Orzack, M.H., Taylor, C.L. & Kornetsky, C. A research report on the anti-fatigue effects of magnesium pemoline. Psychopharmacologia 13, 413–417 (1968). https://doi.org/10.1007/BF00404956

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  • DOI: https://doi.org/10.1007/BF00404956

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