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Pharmacological modification of the effects of spaced occipital ablations

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Summary

Retention of an avoidance response made to the onset of a change in illumination was measured following temporally spaced bilateral ablation of the occipital cortex of the rat. Twelve days were allowed to pass between the ablation of cortex of the two hemispheres. Post-operative retention was superior when the inter-operative interval was spent in the light and noise, except when paired with chronic administration of phenobarbital (30 mg/kg/day). Post-operative retention was minimized when the interoperative interval was spent in dark and quiet, except when paired with chronic administration of d-amphetamine (2 mg/kg/ day).

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References

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Author notes

  1. David D. Cole

    Present address: University of North Carolina at Greensboro, USA

  2. Walter R. Sullins Jr.

    Present address: University of Alabama at Huntsville, USA

Authors and Affiliations

  1. Dept. of Psychology, Emory University, 30322, Atlanta, Georgia, USA

    Walter Isaac Ph. D.

Authors
  1. David D. Cole
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  2. Walter R. Sullins Jr.
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  3. Walter Isaac Ph. D.
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Additional information

This work was supported by a grant (MH-04539) from the National Institute of Mental Health to W. Isaac.

This work was done while on a Post Doctoral Fellowship, National Institute of Mental Health

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Cole, D.D., Sullins, W.R. & Isaac, W. Pharmacological modification of the effects of spaced occipital ablations. Psychopharmacologia 11, 311–316 (1967). https://doi.org/10.1007/BF00404608

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  • DOI: https://doi.org/10.1007/BF00404608

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